(Q21105362)

P-loop containing nucleoside triphosphate hydrolase

1 reference

RAD50, zinc hook, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rad50/SbcC-type AAA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

1 reference

8 April 2019

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

protein-macromolecule adaptor activity

1 reference

8 April 2019

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

DNA helicase activity

1 reference

26 September 2017

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

single-stranded DNA endodeoxyribonuclease activity

1 reference

26 September 2017

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

ATPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

protein binding

6 references

8 April 2019

ATRX dysfunction induces replication defects in primary mouse cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

CDK targets Sae2 to control DNA-end resection and homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

ATRX dysfunction induces replication defects in primary mouse cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

3'-5' exonuclease activity

1 reference

26 September 2017

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

double-stranded telomeric DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

adenylate kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

G-quadruplex DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

single-stranded telomeric DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

single-stranded DNA endodeoxyribonuclease activity

3'-5' exonuclease activity

site of double-strand break

cell component

1 reference

26 September 2017

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

membrane

1 reference

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

telomere

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

condensed nuclear chromosome

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

Mre11 complex

A balance between elongation and trimming regulates telomere stability in stem cells

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

26 September 2017

26 September 2017

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

26 September 2017

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

membrane

HDA

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

HDA

Mre11 complex

A balance between elongation and trimming regulates telomere stability in stem cells

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

8 April 2019

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

reciprocal meiotic recombination

biological process

1 reference

8 April 2019

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

DNA recombination

1 reference

8 April 2019

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

telomere maintenance via telomerase

1 reference

26 September 2017

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

positive regulation of kinase activity

1 reference

8 April 2019

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

telomeric 3' overhang formation

1 reference

8 April 2019

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

positive regulation of telomere maintenance

1 reference

8 April 2019

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

negative regulation of telomere capping

1 reference

8 April 2019

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

DNA duplex unwinding

1 reference

26 September 2017

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

double-strand break repair

positive regulation of protein autophosphorylation

1 reference

8 April 2019

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

double-strand break repair via nonhomologous end joining

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

regulation of mitotic recombination

1 reference

8 April 2019

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

DNA double-strand break processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

telomere maintenance via recombination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

DNA synthesis involved in DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

1 reference

26 September 2017

chromosome organization involved in meiotic cell cycle

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

regulation of signal transduction by p53 class mediator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

nucleotide phosphorylation

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

8 April 2019

8 April 2019

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

strand displacement

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92878&geneProductId=UniProtKB:Q92878

1 reference

26 September 2017

double-strand break repair via homologous recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

8 April 2019

telomere maintenance via telomerase

telomere capping

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

nucleoside monophosphate phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92878

1 reference

Rad50/SbcC-type AAA domain

1 reference