Wikidata

(Q21105431)

English

Endothelial PAS domain protein 1

mammalian protein found in Homo sapiens

  • HIF2-alpha
  • EPAS1
  • Hypoxia-inducible factor 2-alpha
  • HIF-2-alpha
  • PAS domain-containing protein 2
  • HIF-1alpha-like factor
  • member of PAS protein 2
  • endothelial PAS domain-containing protein 1
  • HIF-1-alpha-like factor
  • HLF
  • basic-helix-loop-helix-PAS protein MOP2
  • hypoxia-inducible factor 2 alpha
  • bHLHe73
  • EPAS-1
  • class E basic helix-loop-helix protein 73
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
16 references
retrieved
8 April 2019
stated in
Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization
GOA
curator
UniProt
UniProt protein ID
Q99814
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline
GOA
curator
UniProt
UniProt protein ID
Q99814
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
An oxygen-regulated switch in the protein synthesis machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Artificial ligand binding within the HIF2  PAS-B domain of the HIF2 transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel interaction partners of Bardet-Biedl syndrome proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel interaction partners of Bardet-Biedl syndrome proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IPI
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IEA
IGI
5 references
retrieved
8 April 2019
stated in
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IGI
retrieved
8 April 2019
stated in
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IEA
retrieved
8 April 2019
stated in
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha
GOA
curator
UniProt
UniProt protein ID
Q99814
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814
determination method or standard
IBA

Identifiers

 
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