(Q24298432)

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Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation

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Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation (English)

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Futoshi Shibasaki

4

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Futoshi Shibasaki

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author name string

Li Chen

1

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Kazuyo Uchida

2

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Alexander Endler

3

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publication date

27 April 2007

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Journal of Biological Chemistry

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282

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17

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12707-16

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Subcellular localization and regulation of hypoxia-inducible factor-2alpha in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Endothelium-intrinsic requirement for Hif-2alpha during vascular development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Evidence for the transforming activity of a truncated Int6 gene, in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Characterization of the interaction between the interferon-induced protein P56 and the Int6 protein encoded by a locus of insertion of the mouse mammary tumor virus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

The SCF ubiquitin ligase: an extended look

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Protein homeostasis: a degrading role for Int6/eIF3e

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

HIF-1 and mechanisms of hypoxia sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Identification of novel VHL target genes and relationship to hypoxic response pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Inducible expression of endothelial PAS domain protein-1 by hypoxia in human lung adenocarcinoma A549 cells. Role of Src family kinases-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Int6 expression can predict survival in early-stage non-small cell lung cancer patients.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

21 January 2018

Nuclear localization of hypoxia-inducible factor-2alpha in bovine arterial endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

7 January 2021

based on heuristic

inferred from DOI database lookup

Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700423200

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1074/JBC.M700423200

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