(Q21106682)

Dynamin-like 120kDa protein, mitochondrial

1 reference

Transporter Classification Database ID

membrane fusion pore

1 reference

1.N.6.1.2

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Dynamin, GTPase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

dynamin

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

20 March 2016

language of work or name

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

2 references

7 references

8 April 2019

WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Vital function of PRELI and essential requirement of its LEA motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

magnesium ion binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

3 references

31 October 2017

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

phosphatidic acid binding

1 reference

8 April 2019

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

5 references

8 April 2019

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

integral component of membrane

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrial intermembrane space

3 references

8 April 2019

Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrial outer membrane

1 reference

8 April 2019

Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

extrinsic component of mitochondrial inner membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrial inner membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

mitochondrial membranes

1 reference

31 October 2017

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

4 references

8 April 2019

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

8 April 2019

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

inner mitochondrial membrane organization

IGI

1 reference

8 April 2019

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrial genome maintenance

1 reference

8 April 2019

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

IMP

mitochondrial fission

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

negative regulation of release of cytochrome c from mitochondria

1 reference

8 April 2019

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrion organization

4 references

8 April 2019

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of dendrite development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

axonal transport of mitochondrion

1 reference

8 April 2019

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of mitochondrial fusion

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of neuron maturation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

dynamin family protein polymerization involved in mitochondrial fission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

regulation of apoptotic process

IBA

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60313&geneProductId=UniProtKB:O60313

intracellular distribution of mitochondria

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of dendritic spine morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

mitochondrion morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

response to muscle activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

GTP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

response to electrical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

response to nutrient levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

calcium import into the mitochondrion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

retina development in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of cellular response to insulin stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

cellular response to L-glutamate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

negative regulation of apoptotic process

1 reference

8 April 2019

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

positive regulation of insulin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60313

Dynamin-type guanine nucleotide-binding (G) domain

has part(s)

1 reference

Dynamin, GTPase domain

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1.N.6.1.2

2 references

Transporter Classification database

retrieved

13 March 2020