Wikidata

(Q21107331)

English

NEDD4 E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

  • receptor-potentiating factor 1
  • NEDD4
  • HECT-type E3 ubiquitin transferase NEDD4
  • cell proliferation-inducing gene 53 protein
  • Neural precursor cell expressed developmentally down-regulated protein 4
  • neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
  • E3 ubiquitin-protein ligase NEDD4
  • NEDD-4
  • Nedd4 Ubiquitin Protein Ligases
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Rak functions as a tumor suppressor by regulating PTEN protein stability and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IPI
cell component
biological process
protein ubiquitination
determination method
IDA
IEA
6 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IEA
retrieved
26 September 2017
stated in
Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
26 September 2017
stated in
ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
26 September 2017
stated in
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
26 September 2017
stated in
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P46934&geneProductId=UniProtKB:P46934
determination method
IDA
protein ubiquitination
determination method
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IEA
retrieved
8 April 2019
stated in
ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
8 April 2019
stated in
Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
GOA
curator
UniProt
UniProt protein ID
P46934
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
8 April 2019
stated in
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
8 April 2019
stated in
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46934
determination method
IBA

Identifiers

MeSH descriptor ID
D000075702
subject named as
Nedd4 Ubiquitin Protein Ligases
0 references
PDB structure ID
 
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