(Q28117749)

4 January 2017

title

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis (English)

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Phosphatase and tensin homolog

4 January 2017

main subject

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WW domain containing E3 ubiquitin protein ligase 2

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NEDD4 E3 ubiquitin protein ligase

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OTU deubiquitinase 3

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Ubiquitin specific peptidase 13

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Ubiquitin specific peptidase 7

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monoubiquitinated protein deubiquitination

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Ubiquitin specific peptidase 7

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Phosphatase and tensin homolog

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Neural precursor cell expressed, developmentally down-regulated 4

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Ubiquitin specific peptidase 13 (isopeptidase T-3)

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OTU domain containing 3

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WW domain containing E3 ubiquitin protein ligase 2

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author name string

Lin Yuan

1

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4 January 2017

Yanrong Lv

2

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4 January 2017

Hongchang Li

3

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4 January 2017

Haidong Gao

4

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4 January 2017

Shanshan Song

5

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4 January 2017

Yuan Zhang

6

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4 January 2017

Guichun Xing

7

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4 January 2017

Xiangzhen Kong

8

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4 January 2017

Lijing Wang

9

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4 January 2017

Yang Li

10

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4 January 2017

Tao Zhou

11

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4 January 2017

Daming Gao

12

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4 January 2017

Zhi-Xiong Xiao

13

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4 January 2017

Yuxin Yin

14

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4 January 2017

Wenyi Wei

15

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4 January 2017

Fuchu He

16

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4 January 2017

Lingqiang Zhang

17

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4 January 2017

publication date

1 September 2015

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4 January 2017

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4 January 2017

volume

17

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4 January 2017

issue

9

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4 January 2017

page(s)

1169–1181

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

4 January 2017

cites work

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 April 2017

1 reference

Pten is essential for embryonic development and tumour suppression

21 April 2017

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 April 2017

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 April 2017

1 reference

Essential role for nuclear PTEN in maintaining chromosomal integrity

21 April 2017

1 reference

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

21 April 2017

1 reference

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 April 2017

1 reference

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

21 April 2017

1 reference

Breaking the chains: structure and function of the deubiquitinases

21 April 2017

1 reference

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

21 April 2017

1 reference

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

21 April 2017

1 reference

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

21 April 2017

1 reference

DUBA: a deubiquitinase that regulates type I interferon production

21 April 2017

1 reference

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

21 April 2017

1 reference

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

21 April 2017

1 reference

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

21 April 2017

1 reference

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

21 April 2017

1 reference

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

21 April 2017

1 reference

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

21 April 2017

1 reference

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 April 2017

1 reference

Phosphorylation of the PTEN tail regulates protein stability and function

21 April 2017

1 reference

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

21 April 2017

1 reference

CHD5 is a tumor suppressor at human 1p36

21 April 2017

1 reference

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 April 2017

1 reference

Endogenous viruses: insights into viral evolution and impact on host biology

21 April 2017

1 reference

21 April 2017

Modes of p53 regulation

1 reference

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

21 April 2017

1 reference

WWP2 is an E3 ubiquitin ligase for PTEN.

21 January 2018

1 reference

The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

21 January 2018

1 reference

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

21 January 2018

1 reference

Subtle variations in Pten dose determine cancer susceptibility

21 January 2018

1 reference

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

21 January 2018

1 reference

PTEN level in tumor suppression: how much is too little?

21 January 2018

1 reference

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

21 January 2018

1 reference

The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells

21 January 2018

1 reference

Deubiquitylation and stabilization of PTEN by USP13

21 January 2018

1 reference

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

21 January 2018

1 reference

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

21 January 2018

1 reference

Reduced expression of PTEN correlates with breast cancer progression

21 January 2018

1 reference

Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.

21 January 2018

1 reference

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

A20: from ubiquitin editing to tumour suppression

21 January 2018

1 reference

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

21 January 2018

1 reference

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

21 January 2018

1 reference

Regulation of PTEN by Rho small GTPases

21 January 2018

1 reference

KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death

21 January 2018

1 reference

Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer

21 January 2018

1 reference

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

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The functions and regulation of the PTEN tumour suppressor

21 January 2018

1 reference

12 December 2020

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor

1 reference

12 December 2020

Transgenic Polyoma middle-T mice model premalignant mammary disease

1 reference

12 December 2020

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas

1 reference

12 December 2020

Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer

1 reference

12 December 2020