(Q21107812)

30 September 2019

hierarchical database ID heuristic

part of

RyR/IP3 receptor binding core, RIH domain superfamily

1 reference

Mir domain superfamily

1 reference

inositol 1,4,5-trisphosphate receptors

2 references

Transporter Classification Database ID

1.A.3.2.6

2 October 2019

hierarchical database ID heuristic

Armadillo-type fold

1 reference

Inositol 1,4,5-trisphosphate/ryanodine receptor domain, protein family

1 reference

Ion transport domain, protein family

1 reference

MIR motif domain, protein family

1 reference

RyR/IP3R Homology associated domain, protein family

1 reference

RIH domain, protein family

1 reference

calcium channel inhibitor activity

1 reference

18 July 2018

1 reference

18 July 2018

1 reference

8 April 2019

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

IDA

4 references

31 October 2017

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

calcium ion transmembrane transporter activity

1 reference

8 April 2019

Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

7 references

8 April 2019

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

5 references

8 April 2019

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

phosphatidylinositol binding

3 references

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

platelet dense tubular network

1 reference

8 April 2019

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

endoplasmic reticulum membrane

IDA

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

sarcoplasmic reticulum

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

nuclear inner membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

platelet dense granule membrane

1 reference

8 April 2019

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

platelet dense tubular network membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

transport vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

endoplasmic reticulum

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

endoplasmic reticulum membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

cytoplasmic vesicle membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

secretory granule membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

Schaffer collateral - CA1 synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

regulation of cardiac conduction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

voluntary musculoskeletal movement

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

epithelial fluid transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

post-embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

endoplasmic reticulum calcium ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy

regulation of autophagy

1 reference

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

transmembrane transport

1 reference

8 April 2019

negative regulation of calcium-mediated signaling

1 reference

8 April 2019

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

inositol phosphate-mediated signaling

IDA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation

calcium ion transport

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

1 reference

8 April 2019

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

regulation of molecular function

NAS

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643

release of sequestered calcium ion into cytosol

3 references

regulation of postsynaptic cytosolic calcium ion concentration

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643

physically interacts with

adenophostin A

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4124

language of work or name

English

17 August 2016

adenosine triphosphate

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1713

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

407

language of work or name

English

Inositol 1,4,5-trisphosphate/ryanodine receptor domain

17 August 2016

has part(s)

1 reference

RIH domain

1 reference

Ion transport domain

1 reference

RyR/IP3R Homology associated domain

1 reference

MIR motif

1 reference

http://www.uniprot.org/uniprot/P11881.txt?version=182

Identifiers

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 July 2018

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 November 2015

1 reference

9 November 2015

http://www.uniprot.org/uniprot/P11881.txt?version=182

Transporter Classification Database ID

1.A.3.2.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database