(Q21108118)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28335

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

signal transducer activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

G protein-coupled serotonin receptor activity

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

21 June 2018

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

Gq/11-coupled serotonin receptor activity

1 reference

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

3 references

8 April 2019

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

integral component of plasma membrane

3 references

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

release of sequestered calcium ion into cytosol

biological process

1 reference

21 June 2018

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

positive regulation of phosphatidylinositol biosynthetic process

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

cellular calcium ion homeostasis

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

cGMP biosynthetic process

1 reference

1 January 2018

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

21 June 2018

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

serotonin receptor signaling pathway

1 reference

8 April 2019

Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

4 references

8 April 2019

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

positive regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

chemical synaptic transmission

1 reference

21 June 2018

Sound-induced seizures in serotonin 5-HT2c receptor mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28335&geneProductId=UniProtKB:P28335

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy

cGMP-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28335

phospholipase C-activating G protein-coupled receptor signaling pathway

release of sequestered calcium ion into cytosol

physically interacts with

IMP

1 reference

2941

17 August 2016

5-carboxamidotryptamine

1 reference

4

17 August 2016

1 reference

5

N,N-dimethyl-5-methoxytryptamine

17 August 2016

1 reference

145

17 August 2016

1 reference

107

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

1 reference

7

17 August 2016

1 reference

160

17 August 2016

1 reference

152

17 August 2016

1 reference

34

17 August 2016

1 reference

163

17 August 2016

1 reference

161

17 August 2016

1 reference

37

17 August 2016

1 reference

109

4-iodo-2,5-dimethoxyphenylisopropylamine

17 August 2016

1 reference

147

lysergic acid diethylamide

17 August 2016

1 reference

17

17 August 2016

1 reference

150

17 August 2016

1 reference

165

17 August 2016

1 reference

170

17 August 2016

1 reference

171

17 August 2016

1 reference

124

17 August 2016

1 reference

2

17 August 2016

1 reference

173

17 August 2016

1 reference

23

1-(3-trifluoromethylphenyl)piperazine

17 August 2016

1 reference

115

17 August 2016

1 reference

125

17 August 2016

1 reference

168

17 August 2016

1 reference

230

17 August 2016

1 reference

10

17 August 2016

1 reference

35

17 August 2016

1 reference

149

17 August 2016

1 reference

14

17 August 2016

m-chlorophenylpiperazine

1 reference

142

17 August 2016

1 reference

43

17 August 2016

1 reference

48

17 August 2016

1 reference

28

17 August 2016

1 reference

198

17 August 2016

1 reference

33

17 August 2016

1 reference

83

17 August 2016

1 reference

84

17 August 2016

1 reference

202

17 August 2016

1 reference

186

17 August 2016

1 reference

88

17 August 2016

1 reference

7227

17 August 2016

1 reference

134

17 August 2016

1 reference

7241

17 August 2016

1 reference

209

17 August 2016

1 reference

97

17 August 2016

1 reference

52

17 August 2016

1 reference

187

17 August 2016

1 reference

188

17 August 2016

1 reference

210

17 August 2016

1 reference

221

17 August 2016

1 reference

189

17 August 2016

1 reference

193

17 August 2016

1 reference

194

17 August 2016

1 reference

195

17 August 2016

1 reference

99

17 August 2016

1 reference

175

17 August 2016

1 reference

56

17 August 2016

1 reference

100

17 August 2016

1 reference

213

17 August 2016

1 reference

214

17 August 2016

1 reference

185

17 August 2016

1 reference

7351

17 August 2016

1 reference

57

17 August 2016

1 reference

38

17 August 2016

1 reference

205

17 August 2016

1 reference

206

17 August 2016

1 reference

133

17 August 2016

1 reference

89

17 August 2016

1 reference

135

17 August 2016

1 reference

47

17 August 2016

1 reference

96

17 August 2016

1 reference

98

17 August 2016

1 reference

101

17 August 2016

1 reference

59

17 August 2016

1 reference

103

17 August 2016

1 reference

8689

GPCR, rhodopsin-like, 7TM

17 August 2016

has part(s)

1 reference

InterPro Release 71.0