(Q21108517)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKE5

Citron homology (CNH) domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

3 references

17 October 2017

17 October 2017

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

17 October 2017

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

protein binding

6 references

8 April 2019

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The kinase TNIK is an essential activator of Wnt target genes

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

MAP kinase kinase kinase kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

1 reference

17 October 2017

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

4 references

8 April 2019

8 April 2019

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

3 references

17 October 2017

17 October 2017

Rap2 function requires palmitoylation and recycling endosome localization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

17 October 2017

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

recycling endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

apical plasma membrane

1 reference

8 April 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

extracellular exosome

1 reference

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

4 references

8 April 2019

8 April 2019

Rap2 function requires palmitoylation and recycling endosome localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

extracellular exosome

HDA

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

HDA

presynapse

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

glutamatergic synapse

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

postsynaptic density, intracellular component

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

actin cytoskeleton reorganization

biological process

1 reference

8 April 2019

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

microvillus assembly

1 reference

8 April 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

positive regulation of protein phosphorylation

1 reference

8 April 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

intracellular signal transduction

1 reference

8 April 2019

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

1 reference

8 April 2019

regulation of dendrite morphogenesis

1 reference

8 April 2019

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

4 references

8 April 2019

8 April 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

8 April 2019

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

cytoskeleton organization

1 reference

8 April 2019

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

protein autophosphorylation

protein localization to plasma membrane

1 reference

8 April 2019

Rap2A links intestinal cell polarity to brush border formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

regulation of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

1 reference

17 October 2017

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKE5&geneProductId=UniProtKB:Q9UKE5

1 reference

17 October 2017

MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

activation of protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

neuron projection morphogenesis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKE5

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

346

English

17 August 2016

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016