Wikidata

(Q21109168)

English

Checkpoint kinase 1

mammalian protein found in Homo sapiens

  • cell cycle checkpoint kinase
  • Checkpoint, S. pombe, homolog of, 1
  • Checkpoint kinase-1
  • serine/threonine-protein kinase Chk1
  • CHEK1
  • CHK1 checkpoint homolog
  • Chk1-S
In more languages

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
GOA
curator
UniProt
UniProt protein ID
O14757
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress
GOA
curator
UniProt
UniProt protein ID
O14757
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation
GOA
curator
UniProt
UniProt protein ID
O14757
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
O14757
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Coupling of human circadian and cell cycles by the timeless protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Menin stimulates homology-directed DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
retrieved
8 April 2019
stated in
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14757
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D000071877
subject named as
Checkpoint Kinase 1
0 references
PDB structure ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21109168&oldid=2117464539"