(Q21109504)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92843

Apoptosis regulator, Bcl-W

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92843

Bcl-2 family

1 reference

Transporter Classification Database ID

1.A.21.1.5

2 October 2019

hierarchical database ID heuristic

Apoptosis regulator, Bcl-2 protein, BH4 family

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

Apoptosis regulator, Bcl-2, BH4 motif, conserved site, protein family

1 reference

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

1 reference

13 November 2019

1 reference

13 November 2019

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Human Bop is a novel BH3-only member of the Bcl-2 protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

The structure and interactions of the proline-rich domain of ASPP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

protein homodimerization activity

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

disordered domain specific binding

1 reference

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

identical protein binding

IPI

1 reference

8 April 2019

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

protein heterodimerization activity

IPI

3 references

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

mitochondrial outer membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

Bcl-2 family protein complex

1 reference

8 April 2019

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92843&geneProductId=UniProtKB:Q92843

nuclear inclusion body

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92843&geneProductId=UniProtKB:Q92843

1 reference

8 April 2019

bcl-w, a novel member of the bcl-2 family, promotes cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

regulation of apoptotic process

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

Sertoli cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

negative regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

negative regulation of apoptotic process

3 references

8 April 2019

Testicular degeneration in Bclw-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

cellular response to estradiol stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

cellular response to amyloid-beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92843

physically interacts with

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL443684

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

3 August 2016

1 reference

3 August 2016

1 reference

3 August 2016

1 reference

3 August 2016

1 reference

3 August 2016

Transporter Classification Database ID

English

1.A.21.1.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database