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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
title
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
main subject
apoptotic process
1 reference
based on heuristic
inferred from title
author
Christine Hawkins
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
David T Riglar
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Erinna Lee
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5
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PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Walter D Fairlie
series ordinal
6
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2577705
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
David C Huang
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
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25 December 2019
Jerry Adams
series ordinal
8
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
Jamie Fletcher
series ordinal
1
object named as
Jamie I Fletcher
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
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25 December 2019
author name string
Sarina Meusburger
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
language of work or name
English
0 references
publication date
3 November 2008
1 reference
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Europe PubMed Central
PMC publication ID
2577705
reference URL
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retrieved
25 December 2019
number of pages
7
1 reference
based on heuristic
inferred from page(s)
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
volume
105
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
issue
47
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
page(s)
18081-18087
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
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PubMed Central
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29 September 2017
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29 September 2017
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.
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PubMed Central
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29 September 2017
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes
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29 September 2017
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak
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29 September 2017
The Bcl-2 apoptotic switch in cancer development and therapy
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29 September 2017
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Bcl-xl does not have to bind Bax to protect T cells from death
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PubMed Central
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29 September 2017
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Bax does not have to adopt its final form to drive T cell death
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PubMed Central
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29 September 2017
Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2
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PubMed Central
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29 September 2017
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis
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PubMed Central
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29 September 2017
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
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PubMed Central
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29 September 2017
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
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PubMed Central
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29 September 2017
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
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PubMed Central
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29 September 2017
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
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PubMed Central
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29 September 2017
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
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29 September 2017
Structure of Bax: coregulation of dimer formation and intracellular localization
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29 September 2017
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29 September 2017
Conformation of the Bax C-terminus regulates subcellular location and cell death
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29 September 2017
Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms
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29 September 2017
Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Bim: a novel member of the Bcl-2 family that promotes apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
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29 September 2017
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Bax-independent inhibition of apoptosis by Bcl-XL.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
29 September 2017
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
27 June 2018
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
4 September 2018
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2577705
retrieved
4 September 2018
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18981409
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18981409
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Complete activation of Bax by a single site mutation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18981409
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18981409
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Nonionic detergents induce dimerization among members of the Bcl-2 family
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18981409
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.0808691105
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
ADS bibcode
2008PNAS..10518081F
0 references
PMC publication ID
2577705
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
PubMed publication ID
18981409
1 reference
stated in
Europe PubMed Central
PMC publication ID
2577705
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18981409%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 December 2019
ResearchGate publication ID
23448780
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