(Q29547380)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

review article

1 reference

title

The BCL-2 protein family: opposing activities that mediate cell death (English)

2 references

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23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

1 reference

2

1 reference

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30 December 2019

author name string

Richard J Youle

series ordinal

1

1 reference

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30 December 2019

language of work or name

1 reference

23 April 2017

publication date

1 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Molecular Cell Biology

30 December 2019

published in

2 references

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23 April 2017

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30 December 2019

volume

9

2 references

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23 April 2017

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30 December 2019

page(s)

47-59

2 references

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23 April 2017

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30 December 2019

issue

1

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18097445

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json

Involvement of the bcl-2 gene in human follicular lymphoma

30 December 2019

cites work

1 reference

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

31 March 2020

1 reference

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

31 March 2020

1 reference

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

1 reference

The Bcl-2 apoptotic switch in cancer development and therapy

31 March 2020

1 reference

Oncogene-dependent tumor suppression: using the dark side of the force for cancer therapy.

31 March 2020

1 reference

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

31 March 2020

1 reference

Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators

31 March 2020

1 reference

Promoting apoptosis as a strategy for cancer drug discovery

31 March 2020

1 reference

Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

1 reference

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

31 March 2020

1 reference

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

1 reference

Cell biology. Cellular demolition and the rules of engagement

31 March 2020

1 reference

Mitochondria: releasing power for life and unleashing the machineries of death

31 March 2020

1 reference

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

31 March 2020

1 reference

Which came first, the cytochrome c release or the mitochondrial fission?

31 March 2020

1 reference

Mechanical aspects of apoptosome assembly

31 March 2020

1 reference

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

31 March 2020

1 reference

Generation and characterization of Smac/DIABLO-deficient mice.

31 March 2020

1 reference

Characterization of XIAP-deficient mice

31 March 2020

1 reference

Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense

31 March 2020

1 reference

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

31 March 2020

1 reference

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

31 March 2020

1 reference

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

31 March 2020

1 reference

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

1 reference

Solution structure of the antiapoptotic protein bcl-2

31 March 2020

1 reference

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

31 March 2020

1 reference

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

31 March 2020

1 reference

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

31 March 2020

1 reference

Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

1 reference

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

31 March 2020

1 reference

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

31 March 2020

1 reference

Solution structure of BID, an intracellular amplifier of apoptotic signaling

31 March 2020

1 reference

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

31 March 2020

1 reference

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

31 March 2020

1 reference

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2

31 March 2020

1 reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein

31 March 2020

1 reference

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

31 March 2020

1 reference

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

31 March 2020

1 reference

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

31 March 2020

1 reference

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

31 March 2020

1 reference

BH3-ligand regulates access of MCL-1 to its E3 ligase

31 March 2020

1 reference

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

31 March 2020

1 reference

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

31 March 2020

1 reference

tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

31 March 2020

1 reference

Ion channel activity of the BH3 only Bcl-2 family member, BID.

31 March 2020

1 reference

Molecular evolution of apoptotic pathways: cloning of key domains from sponges (Bcl-2 homology domains and death domains) and their phylogenetic relationships.

31 March 2020

1 reference

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

1 reference

PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

1 reference

PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

1 reference

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

31 March 2020

1 reference

ER stress triggers apoptosis by activating BH3-only protein Bim

31 March 2020

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

1 reference

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

1 reference

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

31 March 2020

1 reference

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

31 March 2020

1 reference

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

31 March 2020

1 reference

NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition

31 March 2020

1 reference

Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

31 March 2020

1 reference

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

31 March 2020

1 reference

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

1 reference

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

1 reference

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

31 March 2020

1 reference

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

31 March 2020

1 reference

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

1 reference

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

31 March 2020

1 reference

A stapled BID BH3 helix directly binds and activates BAX

31 March 2020

1 reference

Regulated targeting of Bax and Bak to intracellular membranes during apoptosis

31 March 2020

1 reference

Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum

31 March 2020

1 reference

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

31 March 2020

1 reference

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

31 March 2020

1 reference

Regulated targeting of BAX to mitochondria.

31 March 2020

1 reference

Movement of Bax from the cytosol to mitochondria during apoptosis

31 March 2020

1 reference

Involvement of the N-terminus of Bax in its intracellular localization and function.

31 March 2020

1 reference

Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3

31 March 2020

1 reference

Nonionic detergents induce dimerization among members of the Bcl-2 family

31 March 2020

1 reference

VDAC2 inhibits BAK activation and mitochondrial apoptosis

31 March 2020

1 reference

Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins

31 March 2020

1 reference

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

31 March 2020

1 reference

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

31 March 2020

1 reference

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

31 March 2020

1 reference

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

31 March 2020

1 reference

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

31 March 2020

1 reference

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

31 March 2020

1 reference

31 March 2020

1 reference

Conformation of the Bax C-terminus regulates subcellular location and cell death

31 March 2020

1 reference

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

31 March 2020

1 reference

Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL.

31 March 2020

1 reference

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

31 March 2020

1 reference

Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

31 March 2020

1 reference

Spatial and temporal changes in Bax subcellular localization during anoikis

31 March 2020

1 reference

Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex

31 March 2020

1 reference

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

31 March 2020

1 reference

Bcl-2 changes conformation to inhibit Bax oligomerization

31 March 2020

1 reference

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

31 March 2020

1 reference

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

31 March 2020

1 reference

The mitochondrial death squad: hardened killers or innocent bystanders?

31 March 2020

1 reference

The pathophysiology of mitochondrial cell death

31 March 2020

1 reference

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation.

31 March 2020

1 reference

Inhibition of Bax channel-forming activity by Bcl-2

31 March 2020

1 reference

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

31 March 2020

1 reference

Bax directly induces release of cytochrome c from isolated mitochondria

31 March 2020

1 reference

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

1 reference

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

31 March 2020

1 reference

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

31 March 2020

1 reference

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

31 March 2020

1 reference

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

31 March 2020

1 reference

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

31 March 2020

1 reference

Mitochondrial fission in apoptosis

31 March 2020

1 reference

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

31 March 2020

1 reference

Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster

31 March 2020

1 reference

Mitochondrial disruption in Drosophila apoptosis.

31 March 2020

1 reference

DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

31 March 2020

1 reference

Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

31 March 2020

1 reference

Role of Bax and Bak in mitochondrial morphogenesis

31 March 2020

1 reference

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

31 March 2020

1 reference

Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

31 March 2020

1 reference

Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

31 March 2020

1 reference

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

1 reference

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

1 reference

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

31 March 2020

1 reference

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

31 March 2020

1 reference

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

31 March 2020

1 reference

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

31 March 2020

1 reference

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

31 March 2020

1 reference

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

Programmed anuclear cell death delimits platelet life span.

31 March 2020

1 reference

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

1 reference

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

1 reference

The role of BH3-only proteins in the immune system

31 March 2020

1 reference

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

1 reference

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

1 reference

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

31 March 2020

1 reference

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

31 March 2020

1 reference

Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation.

31 March 2020

1 reference

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

31 March 2020

1 reference

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

31 March 2020

1 reference

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

1 reference

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

1 reference

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

31 March 2020

1 reference

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

31 March 2020

1 reference

Bad-deficient mice develop diffuse large B cell lymphoma

31 March 2020

1 reference

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

31 March 2020

1 reference

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

31 March 2020

1 reference

BAX is required for neuronal death after trophic factor deprivation and during development

31 March 2020

1 reference

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

31 March 2020

1 reference

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

31 March 2020

1 reference

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

31 March 2020

1 reference

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage

31 March 2020

1 reference

Functional characterization of the Bcl-2 gene family in the zebrafish.

31 March 2020

1 reference

Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.

31 March 2020

1 reference

Conversion of Bcl-2 to a Bax-like death effector by caspases

31 March 2020

1 reference

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

31 March 2020

1 reference

Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18097445

31 March 2020

Identifiers

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

437843

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 December 2019

1038545301

0 references

437843

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18097445

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

437843

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18097445%20AND%20SRC:MED&resulttype=core&format=json