(Q24307663)

BCL2 associated X, apoptosis regulator

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BH3 domain binding

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BCL2-associated X protein

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BCL2-like 1

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1

Loren D Walensky

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Stanley J. Korsmeyer

9

object named as

Stanley J Korsmeyer

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author name string

Kenneth Pitter

2

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Joel Morash

3

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Kyoung Joon Oh

4

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Scott Barbuto

5

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Jill Fisher

6

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Eric Smith

7

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Gregory L Verdine

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

8

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language of work or name

English

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publication date

20 October 2006

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published in

Molecular Cell

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volume

24

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issue

2

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page(s)

199-210

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cites work

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

At the gates of death.

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Apoptotic pathways: ten minutes to dead

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Cell death: critical control points

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Functional immobilization of a DNA-binding protein at a membrane interface via histidine tag and synthetic chelator lipids

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Cardiolipin provides specificity for targeting of tBid to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

BID: a novel BH3 domain-only death agonist

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021

Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.08.020

7 January 2021