(Q52547440)

3 May 2018

title

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. (English)

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3 May 2018

5

Craig B Thompson

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3 May 2018

author name string

Jeffrey C Rathmell

1

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3 May 2018

Tullia Lindsten

2

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3 May 2018

Wei-Xing Zong

3

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3 May 2018

Ryan M Cinalli

4

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3 May 2018

language of work or name

English

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publication date

3 September 2002

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3 May 2018

published in

Nature Immunology

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3 May 2018

volume

3

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3 May 2018

issue

10

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3 May 2018

page(s)

932-939

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3 May 2018

Homeostasis of alpha beta TCR+ T cells.

cites work

1 reference

7 January 2021

Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange

1 reference

7 January 2021

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice

1 reference

7 January 2021

Bcl-XL and Bcl-2 repress a common pathway of cell death

1 reference

7 January 2021

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

1 reference

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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7 January 2021

Bax alpha perturbs T cell development and affects cell cycle entry of T cells

1 reference

7 January 2021

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1 reference

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

7 January 2021

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

7 January 2021

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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7 January 2021

Selection of the T cell repertoire.

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7 January 2021

The role of cytokine receptor signaling in lymphocyte development

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Divergent viral superantigens delete V beta 5+ T lymphocytes

1 reference

7 January 2021

Regulation of thymocyte development from immature progenitors.

1 reference

7 January 2021

Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?

1 reference

7 January 2021

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

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7 January 2021

Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.

1 reference

7 January 2021

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

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7 January 2021

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

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7 January 2021

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice

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7 January 2021

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

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7 January 2021

The action of Bax and bcl-2 on T cell selection

1 reference

7 January 2021

Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells

1 reference

7 January 2021

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1 reference

7 January 2021

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death

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7 January 2021

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

1 reference

7 January 2021

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1 reference

7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1 reference

7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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7 January 2021

Thymocyte development is normal in CTLA-4-deficient mice

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7 January 2021

Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.

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7 January 2021

Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy

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7 January 2021

Identifiers

DOI

10.1038/NI834

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3 May 2018

PubMed ID

12244308

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3 May 2018