(Q36198122)

12 August 2017

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title

Mitochondrial fission in apoptosis (English)

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12 August 2017

mitochondrial fission

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1

Richard J Youle

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12 August 2017

Mariusz Karbowski

2

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12 August 2017

1 August 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

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12 August 2017

6

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12 August 2017

657-663

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12 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrm1697

12 August 2017

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cites work

The division of endosymbiotic organelles

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OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

31 March 2020

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Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

31 March 2020

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Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria

31 March 2020

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

31 March 2020

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

31 March 2020

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Mutation spectrum and splicing variants in the OPA1 gene

31 March 2020

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

31 March 2020

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

31 March 2020

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Structural basis of mitochondrial tethering by mitofusin complexes.

31 March 2020

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Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

31 March 2020

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Mitochondrial fusion intermediates revealed in vitro

31 March 2020

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Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold

31 March 2020

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The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle

31 March 2020

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The dynamin superfamily: universal membrane tubulation and fission molecules?

31 March 2020

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A mitochondrial division apparatus takes shape

31 March 2020

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Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin

31 March 2020

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Mammalian dynamin-like protein DLP1 tubulates membranes

31 March 2020

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Endophilin B1 is required for the maintenance of mitochondrial morphology

31 March 2020

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Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis.

31 March 2020

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Generation of high curvature membranes mediated by direct endophilin bilayer interactions

31 March 2020

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Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals

31 March 2020

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31 March 2020

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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

31 March 2020

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Mutual control of membrane fission and fusion proteins.

31 March 2020

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Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1.

31 March 2020

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Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga

31 March 2020

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Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission

31 March 2020

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Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line

31 March 2020

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Mitochondria as the central control point of apoptosis

31 March 2020

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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

31 March 2020

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

31 March 2020

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

31 March 2020

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Biphasic translocation of Bax to mitochondria

31 March 2020

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Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

31 March 2020

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Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

31 March 2020

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Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis

31 March 2020

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hFis1, a novel component of the mammalian mitochondrial fission machinery

31 March 2020

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Mitochondrial fission proteins regulate programmed cell death in yeast

31 March 2020

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Conformational control of Bax localization and apoptotic activity by Pro168.

31 March 2020

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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

31 March 2020

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Spatial and temporal changes in Bax subcellular localization during anoikis

31 March 2020

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Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.

31 March 2020

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Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax

31 March 2020

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SH3GLB, a new endophilin-related protein family featuring an SH3 domain

31 March 2020

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Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

31 March 2020

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A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

31 March 2020

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The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space

31 March 2020

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Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane

31 March 2020

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

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The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells

31 March 2020

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Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae

31 March 2020

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31 March 2020

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C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane

31 March 2020

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Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.

31 March 2020

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The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance

31 March 2020

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31 March 2020

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Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p

31 March 2020

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Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p

31 March 2020

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The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1

31 March 2020

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The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission

31 March 2020

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Division of mitochondria requires a novel DMN1-interacting protein, Net2p

31 March 2020

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The inner membrane protein Mdm33 controls mitochondrial morphology in yeast

31 March 2020

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UGO1 encodes an outer membrane protein required for mitochondrial fusion

31 March 2020

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Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein

31 March 2020

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Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway.

31 March 2020

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Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis

31 March 2020

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Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics

31 March 2020

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Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death

31 March 2020

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Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission.

31 March 2020

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Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1697

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12 August 2017

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PubMed ID

16025099