(Q44429639)

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Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

scientific article published in May 2003

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12730678%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells (English)

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3 November 2019

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3 November 2019

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Grant Dewson

1

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3 November 2019

Roger T Snowden

2

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3 November 2019

Jason B Almond

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3 November 2019

Gerald M Cohen

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3 November 2019

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1 May 2003

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3 November 2019

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3 November 2019

22

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3 November 2019

2643-2654

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3 November 2019

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3 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206326

0 references

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

1 reference

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21 January 2018

Update on the biology of chronic lymphocytic leukemia

1 reference

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Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

1 reference

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21 January 2018

The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis

1 reference

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21 January 2018

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

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21 January 2018

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

1 reference

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21 January 2018

p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

1 reference

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Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

1 reference

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21 January 2018

Regulated targeting of BAX to mitochondria.

1 reference

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21 January 2018

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

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21 January 2018

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

1 reference

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21 January 2018

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

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21 January 2018

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

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21 January 2018

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL

1 reference

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21 January 2018

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

1 reference

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21 January 2018

Breaking the mitochondrial barrier

1 reference

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21 January 2018

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

1 reference

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21 January 2018

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

1 reference

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21 January 2018

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

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21 January 2018

New agents in cancer clinical trials

1 reference

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7 January 2021

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The proteasome: a novel target for cancer chemotherapy

1 reference

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7 January 2021

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Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex

1 reference

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7 January 2021

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Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

1 reference

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7 January 2021

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The proteasome: paradigm of a self-compartmentalizing protease

1 reference

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7 January 2021

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Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia

1 reference

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7 January 2021

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Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206326

7 January 2021

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The ubiquitin-proteasome proteolytic pathway

1 reference

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7 January 2021

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Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils

1 reference

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7 January 2021

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Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206326

7 January 2021

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

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7 January 2021

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206326

7 January 2021

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p53-dependent induction of apoptosis by proteasome inhibitors

1 reference

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7 January 2021

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Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.

1 reference

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7 January 2021

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Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils

1 reference

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7 January 2021

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Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206326

7 January 2021

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Proteasome inhibitors as anti-cancer agents.

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7 January 2021

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Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance.

1 reference

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7 January 2021

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Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl-2-expressing subclones

1 reference

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7 January 2021

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BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

1 reference

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7 January 2021

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Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1 reference

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7 January 2021

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1 reference

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7 January 2021

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Structure of Bax: coregulation of dimer formation and intracellular localization

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7 January 2021

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Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine

1 reference

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7 January 2021

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

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7 January 2021

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The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

1 reference

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7 January 2021

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