Wikidata

(Q21109659)

English

Cyclin A2

mammalian protein found in Homo sapiens

  • CCNA2
  • cyclin-A
  • cyclin-A2
In more languages

Statements

molecular function
protein binding
determination method
IPI
22 references
retrieved
1 January 2018
stated in
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling
GOA
curator
UniProt
UniProt protein ID
P20248
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of cyclin-dependent kinase activation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Simian virus 40 large T antigen associates with cyclin A and p33cdk2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
retrieved
1 January 2018
stated in
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IPI
cell component
cyclin A2-CDK2 complex
determination method
IBA
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IEA
retrieved
1 January 2018
stated in
Cyclin A is required at two points in the human cell cycle
GOA
curator
UniProt
UniProt protein ID
P20248
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IDA
retrieved
1 January 2018
stated in
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IDA
retrieved
1 January 2018
stated in
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IDA
retrieved
1 January 2018
stated in
Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20248
determination method
IBA
biological process

Identifiers

PDB structure ID
 
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