(Q21112921)

English

Cullin 4B

mammalian protein found in Homo sapiens

cullin-4B
CUL4B

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13620

Cullin homology domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13620

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13620

Cullin repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13620

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13620

Cullin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin protein, neddylation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin protein ligase activity

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

damaged DNA binding

determination method

1 reference

1 January 2018

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

protein binding

determination method

15 references

1 January 2018

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

TIP120A associates with cullins and modulates ubiquitin ligase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

cullin-RING ubiquitin ligase complex

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

determination method

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

extracellular exosome

determination method

1 reference

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

Cul4B-RING E3 ubiquitin ligase complex

determination method

3 references

17 October 2017

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

17 October 2017

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

17 October 2017

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

1 reference

17 October 2017

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

SCF ubiquitin ligase complex

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

Cul4B-RING E3 ubiquitin ligase complex

determination method

4 references

1 January 2018

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

extracellular exosome

determination method

1 reference

1 January 2018

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

biological process

positive regulation of protein catabolic process

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, DNA damage recognition

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

histone H2A monoubiquitination

determination method

1 reference

1 January 2018

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

cellular response to DNA damage stimulus

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13620&geneProductId=UniProtKB:Q13620

determination method

positive regulation of G1/S transition of mitotic cell cycle

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

global genome nucleotide-excision repair

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

transcription-coupled nucleotide-excision repair

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, DNA incision

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

neuron projection development

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

UV-damage excision repair

determination method

1 reference

1 January 2018

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, preincision complex assembly

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, DNA incision, 5'-to lesion

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, DNA duplex unwinding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

nucleotide-excision repair, preincision complex stabilization

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

post-translational protein modification

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

G1/S transition of mitotic cell cycle

determination method

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13620

determination method

Identifiers

RefSeq protein ID

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000360373

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000360373

ENSP00000384109

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000384109

ENSP00000338919

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000338919

ENSP00000360374

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000360374

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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