(Q33112699)

19 July 2017

title

Selective degradation of splicing factor CAPERα by anticancer sulfonamides (English)

1 reference

DDB1 and CUL4 associated factor 15

19 July 2017

main subject

1 reference

RNA binding motif protein 39

1 reference

Cullin 4A

1 reference

Damage specific DNA binding protein 1

1 reference

Cullin 4B

1 reference

3

Koji Sagane

1 reference

19 July 2017

Taisuke Uehara

1

1 reference

19 July 2017

Yukinori Minoshima

2

1 reference

19 July 2017

Naoko Hata Sugi

4

1 reference

19 July 2017

Kaoru Ogawa Mitsuhashi

5

1 reference

19 July 2017

Noboru Yamamoto

6

1 reference

19 July 2017

Hiroshi Kamiyama

7

1 reference

19 July 2017

Kentaro Takahashi

8

1 reference

19 July 2017

Yoshihiko Kotake

9

1 reference

19 July 2017

Mai Uesugi

10

1 reference

19 July 2017

Akira Yokoi

11

1 reference

19 July 2017

Atsushi Inoue

12

1 reference

19 July 2017

Taku Yoshida

13

1 reference

19 July 2017

Miyuki Mabuchi

14

1 reference

19 July 2017

Akito Tanaka

15

1 reference

19 July 2017

Takashi Owa

16

1 reference

19 July 2017

publication date

24 April 2017

1 reference

19 July 2017

published in

Nature Chemical Biology

1 reference

19 July 2017

volume

13

1 reference

19 July 2017

issue

6

1 reference

19 July 2017

page(s)

675-680

1 reference

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

19 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Catalytic in vivo protein knockdown by small-molecule PROTACs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Small-Molecule PROTACS: New Approaches to Protein Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

A phase II study of chloroquinoxaline sulfonamide (CQS) in patients with metastatic colorectal carcinoma (MCRC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Clinical complete long-term remission of a patient with metastatic malignant melanoma under therapy with indisulam (E7070).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Phase I study of E7820, an oral inhibitor of integrin alpha-2 expression with antiangiogenic properties, in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: possible value of integrin alpha2 on platelets as a biological marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Mechanism of auxin perception by the TIR1 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Universal sample preparation method for proteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Multiplexed peptide analysis using data-independent acquisition and Skyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Fast and accurate short read alignment with Burrows-Wheeler transform

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

The RIN: an RNA integrity number for assigning integrity values to RNA measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2363

inferred from DOI database lookup

7 January 2021

based on heuristic

Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28437394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28437394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.2363

1 reference

19 July 2017

1 reference