(Q34478968)

2 August 2017

title

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. (English)

1 reference

2 August 2017

Michael Zengerle

1

1 reference

2 August 2017

Kwok-Ho Chan

series ordinal

2

1 reference

2 August 2017

Alessio Ciulli

series ordinal

3

1 reference

2 August 2017

publication date

16 June 2015

1 reference

2 August 2017

1 reference

2 August 2017

volume

10

1 reference

2 August 2017

issue

8

1 reference

2 August 2017

page(s)

1770-1777

1 reference

The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.

2 August 2017

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6 July 2018

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Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

6 July 2018

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6 July 2018

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The mechanisms behind the therapeutic activity of BET bromodomain inhibition

6 July 2018

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Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells

6 July 2018

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6 July 2018

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Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

6 July 2018

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6 July 2018

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RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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BET domain co-regulators in obesity, inflammation and cancer

6 July 2018

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The bromodomain interaction module

6 July 2018

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From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

6 July 2018

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6 July 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Suppression of inflammation by a synthetic histone mimic

6 July 2018

1 reference

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Selective inhibition of BET bromodomains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4548256

Two-headed PROTAC: an effective new tool for targeted protein degradation

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Chemical genetic control of protein levels: selective in vivo targeted degradation

6 July 2018

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Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

6 July 2018

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

6 July 2018

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Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

6 July 2018

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

6 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26035625

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted degradation of the aryl hydrocarbon receptor by the PROTAC approach: a useful chemical genetic tool

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26035625

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSCHEMBIO.5B00216

1 reference

2 August 2017

1 reference

2 August 2017

1 reference