(Q38185355)

30 August 2017

Bromodomains and their pharmacological inhibitors (English)

1 reference

30 August 2017

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Daniel Gallenkamp

1

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30 August 2017

Kathy A Gelato

series ordinal

2

1 reference

30 August 2017

Bernard Haendler

series ordinal

3

1 reference

30 August 2017

Hilmar Weinmann

series ordinal

4

1 reference

30 August 2017

4 February 2014

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30 August 2017

1 reference

30 August 2017

9

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30 August 2017

438-464

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30 August 2017

3

1 reference

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

30 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Determinants of nucleosome positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Regulation of nucleosome dynamics by histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Nucleosome structure(s) and stability: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

H1 histones: current perspectives and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Emerging roles for chromatin as a signal integration and storage platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The complex language of chromatin regulation during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Regulation of chromatin by histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Fast signals and slow marks: the dynamics of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Decoding the chromatin modification landscape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Epigenetic inheritance: a contributor to species differentiation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Epigenetic inheritance of cell differentiation status

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Altered histone modifications in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Epigenetic programming and risk: the birthplace of cardiovascular disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Targeting deregulated epigenetic control in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

HDAC inhibitors for the treatment of cutaneous T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Molecular pathways: protein methyltransferases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Readers of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Perceiving the epigenetic landscape through histone readers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Operating on chromatin, a colorful language where context matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Targeting epigenetic readers in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain: an acetyl-lysine binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The bromodomain interaction module

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomains as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Brd2 disruption in mice causes severe obesity without Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Regulation of aurora B expression by the bromodomain protein Brd4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Association of bromodomain BET proteins with chromatin requires dimerization through the conserved motif B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The importance of diagnosing NUT midline carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Inhibition of BET bromodomain targets genetically diverse glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET bromodomains mediate transcriptional pause release in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

21 January 2018

WHAT do viruses BET on?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET proteins promote efficient murine leukemia virus integration at transcription start sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

GABAergic neuron deficit as an idiopathic generalized epilepsy mechanism: the role of BRD2 haploinsufficiency in juvenile myoclonic epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain-containing protein 2 gene in photosensitive epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Interaction of gamma-herpesvirus genome maintenance proteins with cellular chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain-dependent stage-specific male genome programming by Brdt

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The role of the double bromodomain-containing BET genes during mammalian spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Malignant genome reprogramming by ATAD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Direct cooperation between androgen receptor and E2F1 reveals a common regulation mechanism for androgen-responsive genes in prostate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A comparative and integrative approach identifies ATPase family, AAA domain containing 2 as a likely driver of cell proliferation in lung adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Regulation of insulin gene transcription by multiple histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PCAF acetylates {beta}-catenin and improves its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The p300/CBP associated factor is frequently downregulated in intestinal-type gastric carcinoma and constitutes a biomarker for clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Is histone acetylation the most important physiological function for CBP and p300?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Genomic occupancy of the transcriptional co-activators p300 and CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

CBP and p300: HATs for different occasions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Histone acetyl transferases as emerging drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

CBP/p300 histone acetyl-transferase activity is important for the G1/S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

p300 is required for orderly G1/S transition in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Pharmacological targeting of lysine acetyltransferases in human disease: a progress report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A novel family of bromodomain genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Dynamics of nucleosome remodelling by individual ACF complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The ACF1 complex is required for DNA double-strand break repair in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Role for hACF1 in the G2/M damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A novel human gene, WSTF, is deleted in Williams syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Williams syndrome is an epigenome-regulator disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

WSTF does it all: a multifunctional protein in transcription, repair, and replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Large-scale organization of ribosomal DNA chromatin is regulated by Tip5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TRIM proteins and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TRIM24 links a non-canonical histone signature to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Trim24 targets endogenous p53 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Trim24 (Tif1 alpha): an essential 'brake' for retinoic acid-induced transcription to prevent liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Sexual dimorphisms in zonal gene expression in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

KAP1 protein: an enigmatic master regulator of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Sumoylation of the transcriptional intermediary factor 1beta (TIF1beta), the Co-repressor of the KRAB Multifinger proteins, is required for its transcriptional activity and is modulated by the KRAB domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

KAP1 is associated with peritoneal carcinomatosis in gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A Poised Chromatin Platform for TGF-β Access to Master Regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TIF1gamma controls erythroid cell fate by regulating transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Small-molecule inhibition of BRDT for male contraception

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Contraception research. Reinventing the pill: male birth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Cyclin-dependent kinase inhibitors move into Phase III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Target structure-based discovery of small molecules that block human p53 and CREB binding protein association

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Mutations truncating the EP300 acetylase in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

Nucleosome structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

7 January 2021

The conserved 12-amino acid stretch in the inter-bromodomain region of BET family proteins functions as a nuclear localization signal

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

7 January 2021

The making of I-BET762, a BET bromodomain inhibitor now in clinical development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

7 January 2021

Histone acetylation-mediated chromatin compaction during mouse spermatogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300434

7 January 2021

Identifiers

DOI

10.1002/CMDC.201300434

1 reference

30 August 2017

1 reference