(Q35668935)

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Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

scientific article published on 14 November 2011

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16 January 2020

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes (English)

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16 January 2020

ribonucleoprotein complex

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16 January 2020

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16 January 2020

Martina Schnölzer

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Martina Schnölzer

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16 January 2020

Katrin Kaehlcke

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Katrin Kaehlcke

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16 January 2020

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Sungyoo Cho

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16 January 2020

Dwayne Bisgrove

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Dwayne Bisgrove

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16 January 2020

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Sebastian Schröder

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16 January 2020

Lei Zeng

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16 January 2020

Qiang Zhang

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16 January 2020

Lily Mak

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16 January 2020

Joann Lau

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16 January 2020

Ming-Ming Zhou

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16 January 2020

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14 November 2011

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16 January 2020

Journal of Biological Chemistry

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16 January 2020

287

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16 January 2020

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16 January 2020

1090-1099

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16 January 2020

The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK

1 reference

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27 July 2018

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains

1 reference

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27 July 2018

HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP

1 reference

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27 July 2018

CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation

1 reference

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27 July 2018

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

1 reference

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27 July 2018

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

The transition from transcriptional initiation to elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation

1 reference

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27 July 2018

Brd4 links chromatin targeting to HPV transcriptional silencing

1 reference

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27 July 2018

Controlling the elongation phase of transcription with P-TEFb

1 reference

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27 July 2018

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256921

27 July 2018

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

1 reference

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

1 reference

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27 July 2018

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

1 reference

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27 July 2018

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

1 reference

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BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

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Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

1 reference

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You bet-cha: a novel family of transcriptional regulators

1 reference

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Mediator of Transcriptional Regulation

1 reference

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Structure and function of a human TAFII250 double bromodomain module

1 reference

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The language of covalent histone modifications

1 reference

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1 reference

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1 reference

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12 December 2020

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16 January 2020

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16 January 2020

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16 January 2020

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