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Mediator of Transcriptional Regulation

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Mediator of transcriptional regulation

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Europe PubMed Central

title

Mediator of Transcriptional Regulation (English)

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R D Kornberg

R D

Kornberg

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7 February 2023

Lawrence C. Myers

1

L C

Myers

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7 February 2023

language of work or name

English

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publication date

June 2000

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number of pages

21

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Annual Review of Biochemistry

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volume

69

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page(s)

729-749

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issue

1

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cites work

Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A mediator required for activation of RNA polymerase II transcription in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

General requirement for RNA polymerase II holoenzymes in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Transcription activation in cells lacking TAFIIS.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A CTD function linking transcription to splicing

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Phosphorylation of the C-terminal domain of RNA polymerase II.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PHO5 promoter

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Med8, a subunit of the mediator CTD complex of RNA polymerase II, directly binds to regulatory elements of SUC2 and HXK2 genes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Mediator protein mutations that selectively abolish activated transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Transcriptional activation by recruitment

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

RNA polymerase II cofactor PC2 facilitates activation of transcription by GAL4-AH in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Functional analysis of yeast essential genes using a promoter-substitution cassette and the tetracycline-regulatable dual expression system.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Association of an activator with an RNA polymerase II holoenzyme.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Different upstream transcriptional activators have distinct coactivator requirements

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A kinase-cyclin pair in the RNA polymerase II holoenzyme.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Dissecting the regulatory circuitry of a eukaryotic genome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2alpha homolog that has both positive and negative roles in transcription in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Bdf1, a yeast chromosomal protein required for sporulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Evidence for a mediator cycle at the initiation of transcription.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Chromatin-modifying and -remodeling complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A novel collection of accessory factors associated with yeast RNA polymerase II

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Mechanism and regulation of yeast RNA polymerase II transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Purification of transcription cofactor complex CRSP

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

The ROX3 gene encodes an essential nuclear protein involved in CYC7 gene expression in Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A mammalian SRB protein associated with an RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Negative effect of the transcriptional activator GAL4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

TBP-associated factors are not generally required for transcriptional activation in yeast

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

An activator binding module of yeast RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Global transcription regulators of eukaryotes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

An activator target in the RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Conserved structures of mediator and RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.69.1.729

(Q22065418)

Mediator of Transcriptional Regulation

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