(Q27694755)

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12 March 2020

title

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs (English)

1 reference

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12 March 2020

0 references

13

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12 March 2020

Yoshinori Hirano

16

1 reference

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12 March 2020

author name string

Philip P Chamberlain

1

1 reference

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12 March 2020

Antonia Lopez-Girona

2

1 reference

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12 March 2020

Karen Miller

3

1 reference

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12 March 2020

Gilles Carmel

4

1 reference

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12 March 2020

Barbra Pagarigan

5

1 reference

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12 March 2020

Barbara Chie-Leon

6

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12 March 2020

Emily Rychak

7

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12 March 2020

Laura G Corral

8

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12 March 2020

Yan J Ren

9

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12 March 2020

Maria Wang

10

1 reference

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12 March 2020

Mariko Riley

11

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12 March 2020

Silvia L Delker

12

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12 March 2020

Hideki Ando

14

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12 March 2020

Tomoyuki Mori

15

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12 March 2020

Hiroshi Handa

17

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12 March 2020

Toshio Hakoshima

18

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12 March 2020

Thomas O Daniel

19

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12 March 2020

Brian E Cathers

20

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12 March 2020

publication date

10 August 2014

1 reference

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Nature Structural & Molecular Biology

12 March 2020

published in

1 reference

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12 March 2020

volume

21

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12 March 2020

issue

9

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12 March 2020

page(s)

803-809

1 reference

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The ubiquitin system, disease, and drug discovery

12 March 2020

cites work

1 reference

Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences.

31 March 2020

1 reference

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

31 March 2020

1 reference

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

31 March 2020

1 reference

Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

31 March 2020

1 reference

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

31 March 2020

1 reference

Identification of a primary target of thalidomide teratogenicity

31 March 2020

1 reference

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

31 March 2020

1 reference

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

31 March 2020

1 reference

DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases

31 March 2020

1 reference

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

31 March 2020

1 reference

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

31 March 2020

1 reference

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

31 March 2020

1 reference

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

31 March 2020

1 reference

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

31 March 2020

1 reference

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma

31 March 2020

1 reference

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

31 March 2020

1 reference

Crystal structures of Bacillus subtilis Lon protease

31 March 2020

1 reference

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

31 March 2020

1 reference

Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals

31 March 2020

1 reference

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

31 March 2020

1 reference

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

31 March 2020

1 reference

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5

31 March 2020

1 reference

Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface

31 March 2020

1 reference

Molecular basis of transport and regulation in the Na(+)/betaine symporter BetP

31 March 2020

1 reference

Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli

31 March 2020

1 reference

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

31 March 2020

1 reference

Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response

31 March 2020

1 reference

Assessment of the effectiveness of animal developmental toxicity testing for human safety

31 March 2020

1 reference

Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease

31 March 2020

1 reference

Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy

31 March 2020

1 reference

The JAZ family of repressors is the missing link in jasmonate signalling.

31 March 2020

1 reference

Mechanism of auxin perception by the TIR1 ubiquitin ligase

31 March 2020

1 reference

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

31 March 2020

1 reference

Processing of X-ray diffraction data collected in oscillation mode

31 March 2020

1 reference

Methods used in the structure determination of bovine mitochondrial F1 ATPase

31 March 2020

1 reference

Matrix methods for solving protein substructures of chlorine and sulfur from anomalous data

31 March 2020

1 reference

The application of multivariate statistical techniques improves single-wavelength anomalous diffraction phasing.

31 March 2020

1 reference

Recent advances in the CRANK software suite for experimental phasing

31 March 2020

1 reference

Features and development of Coot

31 March 2020

1 reference

REFMAC5 for the refinement of macromolecular crystal structures

31 March 2020

1 reference

Phasercrystallographic software

31 March 2020

1 reference

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2874

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25108355%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 March 2020

1042667121

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

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