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Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
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title
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
(English)
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PubMed
part of the series
Gene Wiki Review Series
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author name string
Jeffrey Hannah
series ordinal
1
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Pengbo Zhou
series ordinal
2
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Crossref
language of work or name
English
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PubMed
publication date
15 November 2015
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PubMed
published in
Gene
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PubMed
volume
573
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PubMed
issue
1
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PubMed
page(s)
33-45
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PubMed
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Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus
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A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.
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CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
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Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase
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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
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Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
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Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
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Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
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PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
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The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A
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WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase
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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle
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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
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DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
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CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
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CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
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Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
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20 March 2017
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1
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Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases
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Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells
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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
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20 March 2017
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
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The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5
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20 March 2017
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.
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Hepatitis B virus X protein interacts with a probable cellular DNA repair protein
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Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells
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20 March 2017
Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint
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Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2
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20 March 2017
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas
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20 March 2017
Variants in CUL4B are associated with cerebral malformations
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20 March 2017
Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability
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The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
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20 March 2017
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase
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Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation
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20 March 2017
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis
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20 March 2017
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
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20 March 2017
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase
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20 March 2017
CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
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NUP98 dysregulation in myeloid leukemogenesis
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20 March 2017
Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation
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20 March 2017
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor
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20 March 2017
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
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20 March 2017
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination
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PubMed Central
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20 March 2017
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
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20 March 2017
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis
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20 March 2017
Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
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Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer
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20 March 2017
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression
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Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
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20 March 2017
CUL-4A is critical for early embryonic development
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20 March 2017
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
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7 April 2017
Proteomics. Tissue-based map of the human proteome
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27 November 2018
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12 December 2020
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The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels
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29 September 2017
Accelerated hepatocellular carcinoma development in CUL4B transgenic mice
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29 September 2017
Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein
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29 September 2017
Lenalidomide induces degradation of IKZF1 and IKZF3.
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29 September 2017
CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.
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29 September 2017
HBx affects CUL4-DDB1 function in both positive and negative manners
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29 September 2017
Lung tumourigenesis in a conditional Cul4A transgenic mouse model.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.
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PubMed Central
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29 September 2017
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Proliferating cell nuclear antigen structure and interactions: too many partners for one dancer?
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29 September 2017
mTORC1 dependent regulation of REDD1 protein stability
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PubMed Central
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29 September 2017
X-linked mental deficiency
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PubMed Central
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29 September 2017
Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.
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PubMed Central
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29 September 2017
The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus
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PubMed Central
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29 September 2017
Understanding cullin-RING E3 biology through proteomics-based substrate identification
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy
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29 September 2017
The application and biology of immunomodulatory drugs (IMiDs) in cancer
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29 September 2017
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.
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29 September 2017
Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Shining a light on xeroderma pigmentosum
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PubMed Central
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29 September 2017
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors
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29 September 2017
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
COP1 is a tumour suppressor that causes degradation of ETS transcription factors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Transgenic mice for cre-inducible overexpression of the Cul4A gene.
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29 September 2017
CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cul4A is essential for spermatogenesis and male fertility
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Structural regulation of cullin-RING ubiquitin ligase complexes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).
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29 September 2017
The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Structural assembly of cullin-RING ubiquitin ligase complexes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cul4A is an oncogene in malignant pleural mesothelioma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
DNA repair in mammalian cells : Nucleotide excision repair: variations on versatility
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29 September 2017
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
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29 September 2017
CDK inhibitors: cell cycle regulators and beyond
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29 September 2017
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Hox genes in hematopoiesis and leukemogenesis.
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29 September 2017
Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.
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29 September 2017
HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34.
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29 September 2017
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cockayne syndrome in adults: review with clinical and pathologic study of a new case
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Nedd8 on cullin: building an expressway to protein destruction.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
A new X linked mental retardation (XLMR) syndrome with short stature, small testes, muscle wasting, and tremor localises to Xq24-q25.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
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29 September 2017
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
29 September 2017
Involvement of the single Cul4 gene of Chinese mitten crab Eriocheir sinensis in spermatogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
2 June 2018
CRL4(CDT2) targets CHK1 for PCNA-independent destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
2 June 2018
A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
2 June 2018
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
2 June 2018
Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
The PCI domain: a common theme in three multiprotein complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5110433
retrieved
27 November 2018
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in node-negative breast cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26344709
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.GENE.2015.08.064
0 references
PMCID
5110433
1 reference
stated in
PubMed
PubMed ID
26344709
1 reference
stated in
PubMed
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