(Q24300692)

DDB1 and CUL4 associated factor 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Hediye Erdjument-Bromage

11

0 references

Paul Tempst

13

0 references

Wei Li

1

object named as

Wei Li

0 references

Ryohei Ishii

object named as

Ryohei Ishii

7

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author name string

Liru You

2

0 references

Jonathan Cooper

3

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Gaia Schiavon

4

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Angela Pepe-Caprio

5

0 references

Lu Zhou

6

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Marco Giovannini

8

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C Oliver Hanemann

9

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Stephen B Long

10

0 references

Pengbo Zhou

12

0 references

Filippo G Giancotti

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

14

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language of work or name

English

0 references

publication date

19 February 2010

0 references

published in

Cell

0 references

volume

140

0 references

issue

4

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page(s)

477-90

0 references

cites work

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

19 March 2017

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

19 March 2017

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Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

19 March 2017

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Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

19 March 2017

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Wnt/beta-catenin signaling in development and disease

19 March 2017

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CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

19 March 2017

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VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

19 March 2017

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Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

19 March 2017

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

19 March 2017

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

19 March 2017

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p21-activated kinase links Rac/Cdc42 signaling to merlin

19 March 2017

1 reference

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ERM proteins and merlin: integrators at the cell cortex

19 March 2017

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Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling

7 April 2017

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NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

27 September 2017

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Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex

27 September 2017

1 reference

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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development

27 September 2017

1 reference

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Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma

27 September 2017

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Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.

27 September 2017

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Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression

27 September 2017

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Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling

27 September 2017

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

27 September 2017

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

27 September 2017

1 reference

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Shedding light on Merlin's wizardry

27 September 2017

1 reference

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Hippo signaling in organ size control

27 September 2017

1 reference

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Ubiquitin proteasome system (UPS): what can chromatin do for you?

27 September 2017

1 reference

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Delineation of a Fat tumor suppressor pathway

27 September 2017

1 reference

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Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

27 September 2017

1 reference

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

27 September 2017

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

27 September 2017

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Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

27 September 2017

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Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.

27 September 2017

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Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

27 September 2017

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Functional analysis of neurofibromatosis 2 (NF2) missense mutations

27 September 2017

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Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.

27 September 2017

1 reference

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An alternative domain determines nuclear localization in multifunctional protein 4.1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2828953

Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2828953

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2828953

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2828953

Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings

19 June 2018

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PubMed

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12 December 2020

inferred from PubMed ID database lookup

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

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PubMed

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12 December 2020

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Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

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7 January 2021

Elucidation of a universal size-control mechanism in Drosophila and mammals

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7 January 2021

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis

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7 January 2021

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

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7 January 2021

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

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7 January 2021

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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7 January 2021

Isolation and mass spectrometry of transcription factor complexes

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7 January 2021

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

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7 January 2021

TEAD mediates YAP-dependent gene induction and growth control

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Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

20178741

1 reference