(Q28290857)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

title

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

author name string

Yasushi Shiomi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Hiroka Iida

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Masato Michishita

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Toshihiro Takami

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Toshiki Tsurimoto

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

language of work or name

English

0 references

publication date

14 August 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

12 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

volume

283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

issue

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

page(s)

29045-29052

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

12 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2662008/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells

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DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

20 March 2017

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

20 March 2017

1 reference

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Preventing re-replication of chromosomal DNA.

20 March 2017

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20 March 2017

1 reference

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Loss of Geminin induces rereplication in the presence of functional p53

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

20 March 2017

1 reference

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CDK inhibitors: positive and negative regulators of G1-phase progression

20 March 2017

1 reference

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Ubiquitin ligases: cell-cycle control and cancer

20 March 2017

1 reference

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Proliferating cell nuclear antigen (PCNA): a dancer with many partners

7 April 2017

1 reference

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7 April 2017

1 reference

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Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway

29 September 2017

1 reference

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L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage

29 September 2017

1 reference

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UV Induces p21 rapid turnover independently of ubiquitin and Skp2.

29 September 2017

1 reference

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Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Proliferating cell nuclear antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

29 September 2017

1 reference

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29 September 2017

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29 September 2017

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29 September 2017

1 reference

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A p53-dependent checkpoint pathway prevents rereplication

29 September 2017

1 reference

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29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

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29 September 2017

1 reference

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29 September 2017

1 reference

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UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662008

CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

2 June 2018

1 reference

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Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806045200

The reconstituted human Chl12-RFC complex functions as a second PCNA loader

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806045200

Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806045200

Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806045200

The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806045200

Ordering S phase and M phase in the cell cycle

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18703516

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18703516

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M806045200

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18703516%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

18703516

2 references