(Q40430425)

20 September 2017

title

Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase (English)

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20 September 2017

3

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20 September 2017

David Y Takeda

1

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20 September 2017

Jeffrey D Parvin

series ordinal

2

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20 September 2017

language of work or name

English

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publication date

25 April 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

24

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20 September 2017

page(s)

23416-23423

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Replication licensing--defining the proliferative state?

20 September 2017

cites work

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DNA replication in eukaryotic cells

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Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

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S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

21 January 2018

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Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

21 January 2018

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

21 January 2018

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Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

21 January 2018

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A p53-dependent checkpoint pathway prevents rereplication

21 January 2018

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

21 January 2018

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Loss of Geminin induces rereplication in the presence of functional p53

21 January 2018

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The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase

21 January 2018

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

21 January 2018

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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

21 January 2018

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

21 January 2018

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Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region

21 January 2018

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Skp2-mediated degradation of p27 regulates progression into mitosis

21 January 2018

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

21 January 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

21 January 2018

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Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases

21 January 2018

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Multiple mechanisms regulate subcellular localization of human CDC6.

21 January 2018

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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

21 January 2018

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A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

21 January 2018

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

21 January 2018

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Functional domains of the Xenopus replication licensing factor Cdt1

21 January 2018

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Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

21 January 2018

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

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Role for Cdk1 (Cdc2)/cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosis

21 January 2018

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Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.

21 January 2018

1 reference

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

21 January 2018

1 reference

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Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.

21 January 2018

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Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis

21 January 2018

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Oncogenic potential of the DNA replication licensing protein CDT1

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501208200

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20 September 2017

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