Wikidata

(Q21113750)

English

Dishevelled segment polarity protein 3

mammalian protein found in Homo sapiens

  • segment polarity protein dishevelled homolog DVL-3
  • DVL3
  • dishevelled, dsh homolog 3
  • dishevelled 3 (homologous to Drosophila dsh)
  • DSH homolog 3
In more languages

Statements

molecular function
protein binding
determination method
IPI
20 references
retrieved
8 April 2019
stated in
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling
GOA
curator
UniProt
UniProt protein ID
Q92997
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
Q92997
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
The Hippo pathway regulates Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IPI
cell component
biological process
canonical Wnt signaling pathway
determination method
IBA
IDA
IGI
IMP
TAS
6 references
retrieved
8 April 2019
stated in
A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
TAS
retrieved
8 April 2019
stated in
Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IMP
retrieved
8 April 2019
stated in
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IGI
retrieved
8 April 2019
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IDA
retrieved
8 April 2019
stated in
Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92997
determination method
IBA

Identifiers

 
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