(Q21113973)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q969H0

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q969H0

F-box-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q969H0

F-box protein

1 reference

WD40 repeat, protein family

1 reference

WD40 repeat, conserved site, protein family

1 reference

G-protein beta WD-40 repeat, protein family

1 reference

protein-macromolecule adaptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

20 references

8 April 2019

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Cyclin C is a haploinsufficient tumour suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

ubiquitin-protein transferase activator activity

IPI

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

ubiquitin protein ligase binding

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

phosphothreonine residue binding

1 reference

8 April 2019

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

Parkin-FBXW7-Cul1 ubiquitin ligase complex

IBA

cell component

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

SCF ubiquitin ligase complex

IPI

3 references

8 April 2019

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

17 October 2017

The ubiquitin-specific protease USP28 is required for MYC stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

2 references

3 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of epidermal growth factor-activated receptor activity

biological process

1 reference

8 April 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of protein targeting to mitochondrion

1 reference

8 April 2019

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of SREBP signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

cellular response to UV

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

negative regulation of triglyceride biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of hepatocyte proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

sister chromatid cohesion

1 reference

8 April 2019

Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

cellular response to DNA damage stimulus

1 reference

17 October 2017

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

regulation of protein localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

1 reference

16 July 2018

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

vasculature development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

regulation of autophagy of mitochondrion

1 reference

8 April 2019

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of DNA endoreduplication

1 reference

8 April 2019

Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of ubiquitin-protein transferase activity

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

14 January 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

regulation of cell cycle G1/S phase transition

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

regulation of lipid storage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of proteasomal protein catabolic process

1 reference

16 July 2018

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

positive regulation of protein ubiquitination

1 reference

8 April 2019

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

protein polyubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

post-translational protein modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of osteoclast development

1 reference

16 July 2018

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q969H0&geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

protein destabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

regulation of cell migration involved in sprouting angiogenesis

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

positive regulation of ubiquitin-dependent protein catabolic process

3 references

8 April 2019

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

8 April 2019

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q969H0

D08.811.464.938.750.750.750

Identifiers

MeSH descriptor ID

D000073979

subject named as

F-Box-WD Repeat-Containing Protein 7

0 references

MeSH tree code

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference