(Q34444847)

2 August 2017

Cyclin C is a haploinsufficient tumour suppressor (English)

1 reference

Mediator complex subunit 12

2 August 2017

0 references

1 reference

Cyclin-dependent kinase 8

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Marc Mansour

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alban Ordureau

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Taras Kreslavsky

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Charles G. Mullighan

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jeffrey W. Harper

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

33

Iannis Aifantis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

34

Harald von Boehmer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

28

David C Linch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

27

Rosemary E Gale

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

37

A Thomas Look

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

4

Hiroyuki Inuzuka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

36

Wenyi Wei

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

10

Shavali Shaik

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

38

Piotr Sicinski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Na Li

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Anne Fassl

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Joel Chick

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Xiaoyu Li

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lijun Liu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Haizhen Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Bryan King

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alejandro Gutierrez

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Tobias Otto

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lukas Baitsch

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Leah Bury

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Clifford A Meyer

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Nan Ke

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kristin A Mulry

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Michael J Kluk

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Moni Roy

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Sunkyu Kim

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Xiaowu Zhang

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yan Geng

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Agnieszka Zagozdzon

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Sarah Jenkinson

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jean J Zhao

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jon C Aster

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Steven P Gygi

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

26 October 2014

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1080-1091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/ncb3046

7 June 2020

exact match

0 references

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

6 July 2018

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Postinduction dexamethasone and individualized dosing of Escherichia Coli L-asparaginase each improve outcome of children and adolescents with newly diagnosed acute lymphoblastic leukemia: results from a randomized study--Dana-Farber Cancer Institut

6 July 2018

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

6 July 2018

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Dysregulation of CDK8 and Cyclin C in tumorigenesis

6 July 2018

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

6 July 2018

1 reference

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The mutational landscape of head and neck squamous cell carcinoma

6 July 2018

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Physiological relevance of cell cycle kinases

6 July 2018

1 reference

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Notch signaling in solid tumors.

6 July 2018

1 reference

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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

6 July 2018

1 reference

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CDK8 is a positive regulator of transcriptional elongation within the serum response network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Cyclin C regulates human hematopoietic stem/progenitor cell quiescence

6 July 2018

1 reference

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Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

6 July 2018

1 reference

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Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.

6 July 2018

1 reference

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Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol

6 July 2018

1 reference

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The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

6 July 2018

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

6 July 2018

1 reference

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Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression

6 July 2018

1 reference

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Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

6 July 2018

1 reference

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

6 July 2018

1 reference

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

6 July 2018

1 reference

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

6 July 2018

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

6 July 2018

1 reference

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Clinical implication of genome-wide profiling in diffuse large B-cell lymphoma and other subtypes of B-cell lymphoma.

6 July 2018

1 reference

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

6 July 2018

1 reference

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

6 July 2018

1 reference

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Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group

6 July 2018

1 reference

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A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation

6 July 2018

1 reference

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Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma.

6 July 2018

1 reference

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The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

6 July 2018

1 reference

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Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

6 July 2018

1 reference

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Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

6 July 2018

1 reference

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Activating Notch1 mutations in mouse models of T-ALL.

6 July 2018

1 reference

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Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome

6 July 2018

1 reference

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Cyclin C/cdk3 promotes Rb-dependent G0 exit

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Notch1 functions as a tumor suppressor in mouse skin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Defining the region(s) of deletion at 6q16-q22 in human prostate cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

TFIIH is negatively regulated by cdk8-containing mediator complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

A kinase-cyclin pair in the RNA polymerase II holoenzyme.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Allelic imbalance of chromosome 6q in ovarian tumours

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Inducible gene targeting in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

Mapping of target regions of allelic loss in primary breast cancers to 1-cM intervals on genomic contigs at 6q21 and 6q25.3.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCB3046

The prognostic value and overexpression of cyclin A is correlated with gene amplification of both cyclin A and cyclin E in breast cancer patient.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

T cell tumours of disparate phenotype in mice transgenic for Rbtn-2

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4235773

High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

27 October 2018

1 reference

12 December 2020

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Evaluation of malignant and benign gastric biopsy specimens by mRNA expression profile and multivariate statistical methods

1 reference

12 December 2020

A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCB3046

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25344755%20AND%20SRC:MED&resulttype=core&format=json