(Q21114013)

http://www.ebi.ac.uk/interpro/protein/P20138

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20138

Immunoglobulin subtype, protein family

1 reference

Immunoglobulin V-set domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin domain, protein family

1 reference

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

image

CD33 protein.png
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0 references

1 reference

13 November 2019

1 reference

13 November 2019

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

signaling receptor activity

IEA

1 reference

9 May 2019

Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

protein phosphatase binding

1 reference

9 May 2019

Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

integral component of membrane

IPI

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

integral component of plasma membrane

IEA

1 reference

9 May 2019

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

external side of plasma membrane

IEA

1 reference

9 May 2019

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

9 May 2019

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

specific granule membrane

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

tertiary granule membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

1 reference

9 May 2019

Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of cell population proliferation

1 reference

9 May 2019

Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

regulation of immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

neutrophil degranulation

1 reference

9 May 2019

immune response-inhibiting signal transduction

1 reference

9 May 2019

Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

positive regulation of protein secretion

IDA

1 reference

9 May 2019

FRMD4A-cytohesin signaling modulates the cellular release of tau.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of interleukin-1 beta production

1 reference

9 May 2019

Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of interleukin-8 production

1 reference

9 May 2019

Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of calcium ion transport

1 reference

9 May 2019

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

positive regulation of protein tyrosine phosphatase activity

1 reference

9 May 2019

The sialoadhesin CD33 is a myeloid-specific inhibitory receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

negative regulation of monocyte activation

1 reference

9 May 2019

Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20138

physically interacts with

IDA

1 reference

A reference map of the human binary protein interactome

retrieved

16 June 2020