Wikidata

(Q21115408)

English

F-box and WD repeat domain containing 11

mammalian protein found in Homo sapiens

  • F-box and WD repeats protein beta-TrCP2
  • F-box and WD-40 domain protein 1B
  • F-box protein Fbw1b
  • F-box/WD repeat-containing protein 1B
  • F-box/WD repeat-containing protein 11
  • FBXW11
  • HOS
  • homologous to Slimb protein
  • beta-transducin repeat-containing protein 2
  • F-box and WD-40 domain protein 11
In more languages

Statements

molecular function
protein binding
determination method
IPI
23 references
retrieved
8 April 2019
stated in
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Array MAPPIT: high-throughput interactome analysis in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
retrieved
8 April 2019
stated in
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKB1
determination method
IPI
ubiquitin-protein transferase activity
determination method
IEA
NAS
EXP
IDA
TAS
7 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
TAS
retrieved
5 June 2018
stated in
Identification of a family of human F-box proteins
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
NAS
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
IEA
retrieved
5 June 2018
stated in
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
IDA
retrieved
5 June 2018
stated in
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
retrieved
5 June 2018
stated in
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
retrieved
5 June 2018
stated in
Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
ubiquitin-protein transferase activity
determination method
EXP
IBA
IDA
IEA
NAS
TAS
8 references
retrieved
7 November 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
TAS
retrieved
7 November 2018
stated in
Identification of a family of human F-box proteins
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
NAS
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
IEA
retrieved
7 November 2018
stated in
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
GOA
curator
UniProt
UniProt protein ID
Q9UKB1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
IDA
retrieved
7 November 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
IBA
retrieved
7 November 2018
stated in
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
retrieved
7 November 2018
stated in
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
retrieved
7 November 2018
stated in
Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKB1&geneProductId=UniProtKB:Q9UKB1
determination method
EXP
cell component
biological process

Identifiers

 
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