(Q24337717)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

GOA release 2020-03-11

author

Vivian Li

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Teck Yew Low

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Jan P Gerlach

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Shabaz Mohammed

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Albert J.R. Heck

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Madelon M Maurice

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

11

Hans Clevers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

10

Tokameh Mahmoudi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

author name string

Ser Sue Ng

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Paul J Boersema

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Wouter R Karthaus

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

1 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

volume

149

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

1245-1256

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

Mutations of the APC (adenomatous polyposis coli) gene

4 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt/beta-catenin signaling in development and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt/beta-catenin signaling: components, mechanisms, and diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Dishevelled: a mobile scaffold catalyzing development

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

A mechanism for Wnt coreceptor activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Triple SILAC to determine stimulus specific interactions in the Wnt pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

The kinase TNIK is an essential activator of Wnt target genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt signalling in stem cells and cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Decision tree-driven tandem mass spectrometry for shotgun proteomics

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

beta-catenin destruction complex: insights and questions from a structural perspective

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Akt participation in the Wnt signaling pathway through Dishevelled

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt signaling controls the phosphorylation status of beta-catenin.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Frat is dispensable for canonical Wnt signaling in mammals

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

The Wnt signaling pathway in development and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2012.05.002

7 January 2021

10.1016/J.CELL.2012.05.002

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

760071

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

760071

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

760071

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22682247%20AND%20SRC:MED&resulttype=core&format=json