(Q21981220)

English

Axin 1

mammalian protein found in Mus musculus

axin-1
axis inhibition protein 1
protein Fused
Axin1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35625

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35625

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35625

RGS, subdomain 1/3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35625

DIX domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35625

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

DIX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin beta-catenin binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin-1/2, tankyrase-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

26 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein homodimerization activity

determination method

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

signaling receptor complex adaptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

signal transducer activity

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

GTPase activator activity

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein self-association

determination method

1 reference

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

beta-catenin binding

determination method

5 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

Functional domains of axin. Importance of the C terminus as an oligomerization domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

molecular adaptor activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

ubiquitin protein ligase binding

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein kinase binding

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein domain specific binding

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

armadillo repeat domain binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

beta-catenin binding

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

8 April 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

8 April 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

8 April 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

signaling adaptor activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

beta-catenin binding

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

perinuclear region of cytoplasm

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

lateral plasma membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

Wnt signalosome

determination method

1 reference

9 May 2019

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

cytoplasmic microtubule

determination method

1 reference

9 May 2019

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination method

5 references

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

beta-catenin destruction complex

determination method

4 references

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Functional domains of axin. Importance of the C terminus as an oligomerization domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

Golgi apparatus

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

plasma membrane

determination method

6 references

9 May 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

postsynaptic density

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

biological process

axial mesoderm formation

determination method

1 reference

9 May 2019

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

nucleocytoplasmic transport

determination method

1 reference

9 May 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

apoptotic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

protein catabolic process

determination method

1 reference

9 May 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

axial mesoderm development

determination method

1 reference

9 May 2019

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

cytoplasmic microtubule organization

determination method

1 reference

9 May 2019

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

regulation of protein phosphorylation

determination method

1 reference

9 May 2019

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

negative regulation of protein metabolic process

determination method

1 reference

9 May 2019

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

genetic imprinting

determination method

1 reference

9 May 2019

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of protein catabolic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

negative regulation of fat cell differentiation

determination method

1 reference

9 May 2019

Inhibition of adipogenesis by Wnt signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

post-anal tail morphogenesis

determination method

1 reference

9 May 2019

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

embryonic eye morphogenesis

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

positive regulation of JNK cascade

determination method

forebrain anterior/posterior pattern specification

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

lens placode formation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

Wnt-activated signaling pathway involved in forebrain neuron fate commitment

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

protein polyubiquitination

determination method

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

determination of left/right symmetry

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

muscle cell development

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of peptidyl-threonine phosphorylation

determination method

1 reference

9 May 2019

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

sensory perception of sound

determination method

1 reference

9 May 2019

A case of neighboring loci with similar effects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

olfactory placode formation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

activation of protein kinase activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of transforming growth factor beta receptor signaling pathway

determination method

3 references

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

negative regulation of Wnt signaling pathway

determination method

5 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

negative regulation of canonical Wnt signaling pathway

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of JUN kinase activity

determination method

4 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

dorsal/ventral pattern formation

determination method

positive regulation of protein ubiquitination

determination method

3 references

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of GTPase activity

determination method

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Putative tumor suppressor EDD interacts with and up-regulates APC

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

head development

determination method

1 reference

9 May 2019

Generation of Axin1 conditional mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

regulation of canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

Wnt signaling pathway

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

24 April 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625

determination method

Wnt signaling pathway

determination method

3 references

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

negative regulation of Wnt signaling pathway

determination method

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

positive regulation of JNK cascade

determination method

3 references

9 May 2019

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000073974

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000073974

ENSMUSP00000113756

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000113756

ENSMUSP00000132000

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000132000

ENSMUSP00001091662

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00001091662

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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