(Q21115939)

http://www.ebi.ac.uk/interpro/protein/P56704

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein domain specific binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

co-receptor binding

1 reference

1 January 2018

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

protein binding

6 references

1 January 2018

WLS retrograde transport to the endoplasmic reticulum during Wnt secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

receptor ligand activity

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

transcription coactivator activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

endocytic vesicle membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

extracellular region

extracellular exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

Wnt-Frizzled-LRP5/6 complex

1 reference

1 January 2018

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

early endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

Golgi lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

presynapse

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

extracellular space

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

glutamatergic synapse

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

EXP

biological process

somitogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

cellular response to retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

ISS

hemopoiesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of protein phosphorylation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

Wnt signaling pathway involved in forebrain neuroblast division

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of skeletal muscle tissue development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of receptor internalization

1 reference

1 January 2018

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

axis elongation involved in somitogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of collateral sprouting in absence of injury

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

mammary gland development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

platelet activation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

heart looping

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of protein localization to plasma membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

cardiac muscle cell fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

mesoderm development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of mesodermal cell fate specification

1 reference

1 January 2018

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

negative regulation of fat cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

1 reference

1 January 2018

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of microtubule cytoskeleton organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

negative regulation of dopaminergic neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

in utero embryonic development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

negative regulation of axon extension involved in axon guidance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of peptidyl-serine phosphorylation

1 reference

1 January 2018

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of axonogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of B cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

post-anal tail morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of cardiac muscle cell differentiation

1 reference

1 January 2018

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

paraxial mesodermal cell fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of protein tyrosine kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of DNA-binding transcription factor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

extracellular matrix organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of neural precursor cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

synaptic vesicle recycling

1 reference

1 January 2018

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

osteoblast differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

skeletal muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

dorsal/ventral neural tube patterning

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of protein binding

1 reference

1 January 2018

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

platelet aggregation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

midbrain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of protein kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of cell-cell adhesion mediated by cadherin

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of hepatocyte proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

neurogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

spinal cord association neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

axonogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of cytokine production

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of dermatome development

1 reference

1 January 2018

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

somatic stem cell division

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

axon guidance

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

determination of left/right symmetry

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

inner ear morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

hippocampus development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

negative regulation of heart induction by canonical Wnt signaling pathway

1 reference

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of transcription by RNA polymerase II

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

anterior/posterior pattern specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

1 reference

1 January 2018

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

beta-catenin destruction complex disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 reference

1 January 2018

neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56704&geneProductId=UniProtKB:P56704

1 reference

24 April 2018

ISS

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56704&geneProductId=UniProtKB:P56704

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56704&geneProductId=UniProtKB:P56704

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56704&geneProductId=UniProtKB:P56704

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56704&geneProductId=UniProtKB:P56704

positive regulation of canonical Wnt signaling pathway

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of gene expression

1 reference

1 January 2018

The microRNA-29 family in cartilage homeostasis and osteoarthritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

calcium ion transmembrane transport via low voltage-gated calcium channel

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

presynapse assembly

1 reference

1 January 2018

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

negative regulation of neuron death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

positive regulation of core promoter binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of RNA biosynthetic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

cell population proliferation

1 reference

1 January 2018

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

canonical Wnt signaling pathway

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

secondary palate development

1 reference

1 January 2018

Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

cell fate commitment

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

modulation of chemical synaptic transmission

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

regulation of synapse organization

EXP

postsynapse to nucleus signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56704

Wnt protein, conserved site

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P56704

Identifiers

MeSH descriptor ID

D060509

subject named as

Wnt3A Protein

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023