(Q21116071)

Armadillo-type fold

1 reference

Rapamycin-insensitive companion of mTOR, domain 4, protein family

1 reference

Rapamycin-insensitive companion of mTOR, domain 5, protein family

1 reference

Rapamycin-insensitive companion of mTOR, N-terminal domain, protein family

1 reference

Rapamycin-insensitive companion of mTOR, middle domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

19 references

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Activation of mTORC2 by association with the ribosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

enzyme activator activity

IPI

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

31 October 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

31 October 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

31 October 2017

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of protein phosphorylation

IBA

biological process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

actin cytoskeleton reorganization

1 reference

31 October 2017

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

positive regulation of endothelial cell proliferation

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

positive regulation of actin filament polymerization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of actin cytoskeleton organization

1 reference

31 October 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6R327&geneProductId=UniProtKB:Q6R327

regulation of GTPase activity

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

establishment or maintenance of actin cytoskeleton polarity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

multicellular organism development

IBA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

peptidyl-serine phosphorylation

1 reference

1 January 2018

A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of peptidyl-serine phosphorylation

IGI

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

establishment of cell polarity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of inflammatory response

IBA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of gene expression

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

regulation of establishment of cell polarity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

positive regulation of TOR signaling

1 reference

1 January 2018

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

activation of protein kinase B activity

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6R327

actin cytoskeleton reorganization

Rapamycin-insensitive companion of mTOR, domain 4

1 reference

Rapamycin-insensitive companion of mTOR, domain 5

1 reference

Rapamycin-insensitive companion of mTOR, phosphorylation-site

1 reference

Rapamycin-insensitive companion of mTOR, N-terminal domain

1 reference

Rapamycin-insensitive companion of mTOR, middle domain

1 reference

D08.811.913.696.620.682.700.931.750.500

Identifiers

MeSH descriptor ID

D000076226

subject named as

Rapamycin-Insensitive Companion of mTOR Protein

0 references

MeSH tree code

D05.500.356.500

0 references

0 references

D12.644.360.024.323

0 references

D12.776.157.057.156

0 references

D12.776.476.024.411

0 references

D12.776.476.563.931.750.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata