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Apoptosis antagonizing transcription factor
mammalian protein found in Homo sapiens
rb-binding protein Che-1
protein AATF
AATF
Apoptosis-antagonizing transcription factor
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NY61
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NY61
encoded by
AATF
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NY61
molecular function
protein domain specific binding
determination method
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NY61&geneProductId=UniProtKB:Q9NY61
determination method
IEA
DNA-binding transcription factor activity
determination method
IEA
1 reference
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NY61&geneProductId=UniProtKB:Q9NY61
determination method
IEA
leucine zipper domain binding
determination method
IEA
IPI
3 references
retrieved
8 April 2019
stated in
AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
retrieved
8 April 2019
stated in
Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IPI
tau protein binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
RNA binding
determination method
IDA
2 references
retrieved
26 September 2017
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NY61&geneProductId=UniProtKB:Q9NY61
determination method
IDA
retrieved
26 September 2017
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NY61&geneProductId=UniProtKB:Q9NY61
determination method
IDA
RNA binding
determination method
HDA
2 references
retrieved
8 April 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
HDA
retrieved
8 April 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
HDA
protein kinase binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
cell component
cytoplasm
determination method
IDA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
retrieved
8 April 2019
stated in
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
Golgi apparatus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
nucleus
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
retrieved
8 April 2019
stated in
Functional proteomic analysis of human nucleolus
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
retrieved
8 April 2019
stated in
AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
retrieved
8 April 2019
stated in
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
nucleolus
determination method
IBA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IBA
biological process
embryonic cleavage
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
ribosome biogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
negative regulation of apoptotic process
determination method
IMP
1 reference
retrieved
26 September 2017
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NY61&geneProductId=UniProtKB:Q9NY61
determination method
IMP
cellular response to DNA damage stimulus
determination method
IEP
1 reference
retrieved
8 April 2019
stated in
Che-1 activates XIAP expression in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEP
positive regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
cell adhesion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
negative regulation of amyloid precursor protein biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
regulation of mitotic cell cycle
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
negative regulation of superoxide anion generation
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
negative regulation of reactive oxygen species metabolic process
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Che-1 activates XIAP expression in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IDA
negative regulation of apoptotic process
determination method
IEA
IMP
2 references
retrieved
8 April 2019
stated in
AATF protects neural cells against oxidative damage induced by amyloid beta-peptide
GOA
curator
UniProt
UniProt protein ID
Q9NY61
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NY61
determination method
IEA
physically interacts with
Viroporin 3a
determination method
Affinity Capture-MS
1 reference
reference URL
https://thebiogrid.org/news/227
retrieved
19 April 2020
stated in
BioGRID
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Identifiers
RefSeq protein ID
NP_036270
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
26574
XP_011522913
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
26574
UniProt protein ID
Q9NY61
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NY61
Ensembl protein ID
ENSP00000477848
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000477848
ENSP00000481894
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000481894
ENSP00000487925
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000487925
ENSP00000488221
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000488221
ENSP00000477881
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000477881
ENSP00000480472
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000480472
ENSP00000488862
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000488862
ENSP00000479926
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000479926
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