(Q24300117)

Apoptosis antagonizing transcription factor

1 reference

leucine zipper domain binding

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Apoptosis antagonizing transcription factor

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PRKC, apoptosis, WT1, regulator

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Journal of Biological Chemistry

author name string

Qing Guo

series ordinal

1

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Jun Xie

series ordinal

2

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language of work or name

English

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publication date

6 February 2004

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published in

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volume

279

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issue

6

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page(s)

4596-603

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cites work

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A portrait of Alzheimer secretases--new features and familiar faces

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The presenilins in Alzheimer's disease--proteolysis holds the key.

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Alzheimer's disease: genotypes, phenotypes, and treatments

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Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues

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The galvanization of beta-amyloid in Alzheimer's disease

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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

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Amyloid diseases: abnormal protein aggregation in neurodegeneration

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Neuroscience. An accomplice for gamma-secretase brought into focus.

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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Presenilin-1 mutations in Alzheimer's disease.

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The role of presenilin cofactors in the gamma-secretase complex

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Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

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Biology of presenilins as causative molecules for Alzheimer disease.

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Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

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Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

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Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells

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Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide

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Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

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THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies

21 January 2018

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Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter

21 January 2018

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Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease

21 January 2018

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Apoptosis by Par-4 in cancer and neurodegenerative diseases

21 January 2018

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Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3.

21 January 2018

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Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice

21 January 2018

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Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation

21 January 2018

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Evidence for the involvement of Par-4 in ischemic neuron cell death

21 January 2018

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Neurodegenerative disorders and ischemic brain diseases.

21 January 2018

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Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway

21 January 2018

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Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity.

21 January 2018

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Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression

21 January 2018

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Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders

21 January 2018

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

21 January 2018

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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

1 reference

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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

21 January 2018

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Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

21 January 2018

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AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis

21 January 2018

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C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity

21 January 2018

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The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.

21 January 2018

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The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

21 January 2018

1 reference

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DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200

The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis.

21 January 2018

1 reference

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Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway

21 January 2018

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Identification of novel transcription factor-like gene from human intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200

Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200

Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200

The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200

inferred from DOI database lookup

7 January 2021

based on heuristic

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309811200