(Q43751849)

26 November 2017

Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice (English)

1 reference

26 November 2017

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Xie J

1

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26 November 2017

Chang X

series ordinal

2

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26 November 2017

Zhang X

series ordinal

3

1 reference

26 November 2017

Guo Q

series ordinal

4

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26 November 2017

language of work or name

English

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publication date

1 October 2001

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26 November 2017

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26 November 2017

915

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26 November 2017

1

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26 November 2017

1-10

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Cognitive and neurobiologic markers of early Alzheimer disease

26 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Is apoptosis key in Alzheimer's disease?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease: neurodevelopment converges with neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Role of potassium channels in amyloid-induced cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease. Closing in on gamma-secretase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Cell surface expression of the Alzheimer disease-related presenilin proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Protein topology of presenilin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilins: genes for life and death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

The presenilins in Alzheimer's disease--proteolysis holds the key.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

The Alzheimer family of diseases: many etiologies, one pathogenesis?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease: the amyloid cascade hypothesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease: a cell biological perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin interactions and Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Membrane topology of the C. elegans SEL-12 presenilin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Dissecting how presinilins function--and malfunction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilins, Alzheimer's disease, and capacitative calcium entry.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Evidence for a physical interaction between presenilin and Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin-1 mutations in Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Genetic dissection of Alzheimer disease, a heterogeneous disorder

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease. A partner for presenilin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease: genotypes, phenotypes, and treatments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Translating cell biology into therapeutic advances in Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

In search of gamma-secretase: presenilin at the cutting edge

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Expression and function of the leucine zipper protein Par-4 in apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Skeletal and CNS defects in Presenilin-1-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Neuroscience. An accomplice for gamma-secretase brought into focus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin is required for activity and nuclear access of Notch in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin is required for proper morphology and function of neurons in C. elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Mechanisms of neuronal degeneration in Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Presenilin-mediated modulation of capacitative calcium entry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2801%2902803-7

10.1016/S0006-8993(01)02803-7

7 January 2021

Identifiers

DOI

1 reference

26 November 2017

1 reference