(Q28592853)

English

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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scholarly article

1 reference

31 January 2017

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis (English)

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

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0 references

1 reference

GOA release 2020-03-11

author name string

M P Mattson

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

H Zhu

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

J Yu

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

M S Kindy

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

15 February 2000

1 reference

31 January 2017

Journal of Neuroscience

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

20

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

1358-1364

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

4

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dantrolene protects against ischemic, delayed neuronal death in gerbil brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxicity and excitoprotection in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential immunohistochemical localization of inositol 1,4,5-trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stroke risk factors and stroke prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine-induced calcium release from internal stores in cultured rat sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of second messenger systems after transient cerebral ischemia in gerbils: Protective effect of pentobarbital and an autoradiographic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of gelsolin during murine stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dantrolene is cytoprotective in two models of neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dantrolene Prevents Glutamate Cytotoxicity and Ca2+Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rodent models of cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of additional pathology on the cognitive deficit in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10662826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-04-01358.2000

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772370&resulttype=core&format=json

12 May 2020

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