(Q48308608)

10 February 2018

title

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. (English)

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10 February 2018

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7

Mattson MP

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10 February 2018

author name string

Guo Q

1

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10 February 2018

Fu W

2

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10 February 2018

Sopher BL

3

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10 February 2018

Miller MW

4

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10 February 2018

Ware CB

5

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10 February 2018

Martin GM

6

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10 February 2018

language of work or name

English

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publication date

1 January 1999

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10 February 2018

published in

Nature Medicine

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10 February 2018

volume

5

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10 February 2018

issue

1

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10 February 2018

page(s)

101-106

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10 February 2018

https://scigraph.springernature.com/pub.10.1038/4789

exact match

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cites work

Excitatory amino acids and Alzheimer's disease

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7 January 2021

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Presenilins and Alzheimer's disease

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Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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7 January 2021

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

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7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

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7 January 2021

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

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7 January 2021

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

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7 January 2021

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

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7 January 2021

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

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7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

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7 January 2021

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

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7 January 2021

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

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7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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7 January 2021

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

1 reference

7 January 2021

Identifiers

DOI

10.1038/4789

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10 February 2018

PubMed ID

9883847

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10 February 2018