(Q41652301)

6 October 2017

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title

Presenilins and Alzheimer's disease (English)

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6 October 2017

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Kim TW

1

1 reference

PubMed ID

9384549

6 October 2017

Tanzi RE

series ordinal

2

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6 October 2017

1 October 1997

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Current Opinion in Neurobiology

6 October 2017

1 reference

6 October 2017

7

1 reference

6 October 2017

683-688

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6 October 2017

5

1 reference

The gene defects responsible for familial Alzheimer's disease

6 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Presenilins: genes for life and death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Maintenance of somite borders in mice requires the Delta homologue DII1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Developmental regulation of presenilin mRNA expression parallels notch expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease: the Volga German families.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Protein topology of presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Possible role of neuronal apoptosis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

Effect of nitric oxide donors on GABA uptake by rat brain synaptosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2897%2980089-X

7 January 2021

10.1016/S0959-4388(97)80089-X

Identifiers

DOI

1 reference

6 October 2017

1 reference

PubMed ID

9384549