(Q44843668)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

title

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB (English)

1 reference

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9 December 2019

1 reference

3

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9 December 2019

author name string

C C Weihl

1

1 reference

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9 December 2019

G D Ghadge

2

1 reference

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9 December 2019

N Hay

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

R J Miller

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

R P Roos

6

1 reference

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9 December 2019

language of work or name

English

0 references

publication date

1 July 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

volume

19

1 reference

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9 December 2019

issue

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

page(s)

5360-5369

1 reference

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Mechanism of activation and function of protein kinase B.

9 December 2019

cites work

1 reference

12 December 2020

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

12 December 2020

Presenilins are processed by caspase-type proteases.

1 reference

12 December 2020

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

12 December 2020

Phosphorylation and activation of p70s6k by PDK1

1 reference

12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

12 December 2020

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

12 December 2020

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

12 December 2020

Direct association of presenilin-1 with beta-catenin

1 reference

12 December 2020

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

1 reference

12 December 2020

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

12 December 2020

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

12 December 2020

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

12 December 2020

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

12 December 2020

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

12 December 2020

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

1 reference

12 December 2020

Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons

1 reference

12 December 2020

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Glycogen synthase kinase-3: functions in oncogenesis and development

1 reference

12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

12 December 2020

Regulation of apoptosis by presenilin 1.

1 reference

12 December 2020

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

12 December 2020

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

1 reference

12 December 2020

Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription

1 reference

12 December 2020

Wnt signaling: a common theme in animal development

1 reference

12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

12 December 2020

The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway

1 reference

12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

12 December 2020

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

12 December 2020

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

1 reference

12 December 2020

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1 reference

12 December 2020

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

1 reference

12 December 2020

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

12 December 2020

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

10.1523/JNEUROSCI.19-13-05360.1999

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10377346%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

1 reference