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English
Mechanism of activation and function of protein kinase B.
scientific article published on February 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
review article
1 reference
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Europe PubMed Central
title
Mechanism of activation and function of protein kinase B
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
author
Dario Alessi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
author name string
P Cohen
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
publication date
1 February 1998
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
published in
Current Opinion in Genetics & Development
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stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
volume
8
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
page(s)
55-62
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
cites work
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
1 reference
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Crossref
reference URL
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7 January 2021
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PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
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inferred from DOI database lookup
The pleckstrin homology domain: an intriguing multifunctional protein module
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inositol lipid 5-phosphatases--traffic signals and signal traffic.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of protein kinase B by insulin and IGF-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of translocation in the activation and function of protein kinase B
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
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Protein kinase C: structure, function, and regulation
1 reference
stated in
Crossref
reference URL
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7 January 2021
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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
1 reference
stated in
Crossref
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7 January 2021
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The modular phosphorylation and activation of p70s6k.
1 reference
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Crossref
reference URL
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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
1 reference
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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
1 reference
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Crossref
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7 January 2021
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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
1 reference
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Crossref
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7 January 2021
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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
1 reference
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7 January 2021
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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
1 reference
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Crossref
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7 January 2021
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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1 reference
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Crossref
reference URL
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Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
1 reference
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Crossref
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7 January 2021
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PDK1, one of the missing links in insulin signal transduction?
1 reference
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Crossref
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7 January 2021
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Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin
1 reference
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Crossref
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Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades
1 reference
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7 January 2021
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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
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inferred from DOI database lookup
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
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inferred from DOI database lookup
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of neuronal survival by the serine-threonine protein kinase Akt
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
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inferred from DOI database lookup
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
1 reference
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Crossref
reference URL
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7 January 2021
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Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation and activation of p70s6k by PDK1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0959-437X%2898%2980062-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0959-437X(98)80062-2
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
PubMed ID
9529606
1 reference
stated in
Europe PubMed Central
PubMed ID
9529606
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9529606%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 November 2019
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