Wikidata

(Q21116503)

English

Protein phosphatase 1 catalytic subunit alpha

mammalian protein found in Homo sapiens

  • serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
  • protein phosphatase 1, catalytic subunit, alpha isoform
  • serine/threonine-protein phosphatase PP1-alpha catalytic subunit
  • testicular tissue protein Li 155
  • protein phosphatase 1, catalytic subunit, alpha isozyme
  • PPP1CA
In more languages

Statements

molecular function
protein binding
determination method
IPI
39 references
retrieved
9 May 2019
stated in
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
NOM1 targets protein phosphatase I to the nucleolus
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Identification and characterization of a novel human PP1 phosphatase complex
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Protein phosphatase 1α interacting proteins in the human brain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Flexibility in the PP1:spinophilin holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Docking motif-guided mapping of the interactome of protein phosphatase-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Identification of the human testis protein phosphatase 1 interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
retrieved
9 May 2019
stated in
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IPI
cell component
biological process
protein dephosphorylation
determination method
IEA
IMP
ISS
TAS
6 references
retrieved
9 May 2019
stated in
Cloning and characterization of a human protein phosphatase 1-encoding cDNA
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P62136
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
ISS
retrieved
9 May 2019
stated in
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IMP
retrieved
9 May 2019
stated in
Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62136
determination method
IEA

Identifiers

PDB structure ID
 
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