(Q47434210)

English

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

scientific article published on 6 November 2017

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scholarly article

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration (English)

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

phosphorylation

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Catherine Wenhui Goh

1

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Irene Chengjie Lee

2

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Jeyapriya Rajameenakshi Sundaram

3

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Simi Elizabeth George

4

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Permeen Yusoff

5

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Matthew Hayden Brush

6

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Newman Siu Kwan Sze

7

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Shirish Shenolikar

8

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Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

language of work or name

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publication date

6 November 2017

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Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

Journal of Biological Chemistry

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Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

293

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Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

1

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

163-176

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5766914/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases

1 reference

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29 September 2018

Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

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Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly

1 reference

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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

1 reference

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29 September 2018

The integrated stress response.

1 reference

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Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response

1 reference

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1 reference

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TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

1 reference

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1 reference

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G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

1 reference

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Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

1 reference

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29 September 2018

The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum

1 reference

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29 September 2018

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins

1 reference

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1 reference

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The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases

1 reference

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29 September 2018

TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

1 reference

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29 September 2018

Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

TDP-43 identified from a genome wide RNAi screen for SOD1 regulators

1 reference

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29 September 2018

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

1 reference

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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

1 reference

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Toward an understanding of the protein interaction network of the human liver

1 reference

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29 September 2018

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

1 reference

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29 September 2018

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

1 reference

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Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

1 reference

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29 September 2018

Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy

1 reference

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1 reference

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TDP-43 is recruited to stress granules in conditions of oxidative insult.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

29 September 2018

The molecular links between TDP-43 dysfunction and neurodegeneration

1 reference

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29 September 2018

Identification of casein kinase-1 phosphorylation sites on TDP-43.

1 reference

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1 reference

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Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

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1 reference

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Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease

1 reference

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Control of cellular GADD34 levels by the 26S proteasome

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

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1 reference

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1 reference

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1 reference

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1 reference

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Gadd34 requirement for normal hemoglobin synthesis

1 reference

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1 reference

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1 reference

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1 reference

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GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

1 reference

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

1 reference

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29 September 2018

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

1 reference

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Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

1 reference

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Human BAG-1 Proteins Bind to the Cellular Stress Response Protein GADD34 and Interfere with GADD34 Functions

1 reference

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1 reference

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Stress-induced gene expression requires programmed recovery from translational repression

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5766914

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1 reference

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GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/29109149

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M117.814111

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

0 references

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29109149

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