(Q38704807)

5 September 2017

Protein misfolding in the endoplasmic reticulum as a conduit to human disease (English)

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5 September 2017

endoplasmic reticulum

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author name string

Miao Wang

series ordinal

1

1 reference

PubMed ID

26791723

5 September 2017

Randal J Kaufman

series ordinal

2

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PubMed ID

26791723

5 September 2017

language of work or name

English

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publication date

1 January 2016

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5 September 2017

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5 September 2017

529

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5 September 2017

7586

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5 September 2017

326-335

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https://scigraph.springernature.com/pub.10.1038/nature17041

5 September 2017

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cites work

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

21 January 2018

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

21 January 2018

1 reference

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

21 January 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE17041

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Plasma cell differentiation requires the transcription factor XBP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator-activated receptor γ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Atf4 regulates obesity, glucose homeostasis, and energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Regulation of hepatic lipogenesis by the transcription factor XBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The impact of the endoplasmic reticulum protein-folding environment on cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Pharmacological brake-release of mRNA translation enhances cognitive memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17041

Paneth cells as a site of origin for intestinal inflammation.

21 January 2018

1 reference

12 December 2020

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

1 reference

12 December 2020

Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

12 December 2020

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

1 reference

12 December 2020

A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells

1 reference

12 December 2020

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 reference

12 December 2020

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

1 reference

12 December 2020

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

1 reference

12 December 2020

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE17041

1 reference

5 September 2017

1 reference

PubMed ID

26791723