(Q35909430)

11 August 2017

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy (English)

1 reference

11 August 2017

0 references

0 references

10

Ana Maria Cuervo

0 references

Juan Segura-Aguilar

object named as

Juan Segura-Aguilar

9

0 references

Laurie Glimcher

11

object named as

Laurie H Glimcher

1 reference

11 August 2017

6

Craig Wirth

1 reference

11 August 2017

Rene L Vidal

1

1 reference

11 August 2017

Alicia Figueroa

2

1 reference

11 August 2017

Felipe A Court

3

1 reference

11 August 2017

Peter Thielen

4

1 reference

11 August 2017

Claudia Molina

5

1 reference

11 August 2017

Benjamin Caballero

7

1 reference

11 August 2017

Roberta Kiffin

8

1 reference

11 August 2017

Claudio Hetz

12

1 reference

11 August 2017

language of work or name

1 reference

14 February 2012

1 reference

11 August 2017

Human Molecular Genetics

1 reference

11 August 2017

21

1 reference

11 August 2017

2245-2262

1 reference

11 August 2017

10

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3335312/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

27 July 2018

1 reference

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27 July 2018

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IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

27 July 2018

1 reference

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IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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27 July 2018

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JNK regulates FoxO-dependent autophagy in neurons

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease

27 July 2018

1 reference

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Mechanism of ER stress-induced brain damage by IP(3) receptor

27 July 2018

1 reference

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27 July 2018

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27 July 2018

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Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

27 July 2018

1 reference

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Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

27 July 2018

1 reference

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XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum

27 July 2018

1 reference

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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

27 July 2018

1 reference

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Regulation of basal cellular physiology by the homeostatic unfolded protein response

27 July 2018

1 reference

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Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

27 July 2018

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

27 July 2018

1 reference

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

27 July 2018

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

27 July 2018

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The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

27 July 2018

1 reference

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FoxO transcription factors promote autophagy in cardiomyocytes

27 July 2018

1 reference

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Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

27 July 2018

1 reference

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Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

27 July 2018

1 reference

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Mutant huntingtin and mitochondrial dysfunction

27 July 2018

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27 July 2018

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

27 July 2018

1 reference

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Regulation of hepatic lipogenesis by the transcription factor XBP1

27 July 2018

1 reference

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OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

27 July 2018

1 reference

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

27 July 2018

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Autophagy fights disease through cellular self-digestion

27 July 2018

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Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

27 July 2018

1 reference

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Autophagy in the Pathogenesis of Disease

27 July 2018

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

27 July 2018

1 reference

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Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Signal integration in the endoplasmic reticulum unfolded protein response

27 July 2018

1 reference

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

27 July 2018

1 reference

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Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

27 July 2018

1 reference

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Modulating stress responses by the UPRosome: a matter of life and death

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Targeting autophagy in ALS: a complex mission

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Protein misfolding disorders and macroautophagy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Autophagy for tissue homeostasis and neuroprotection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Autophagy gone awry in neurodegenerative diseases

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Expression analysis of novel striatal-enriched genes in Huntington disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Fine structure of the autophagosome.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

The roles of intracellular protein-degradation pathways in neurodegeneration

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Lessons from animal models of Huntington's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Plasma cell differentiation requires the transcription factor XBP-1

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Regulated translation initiation controls stress-induced gene expression in mammalian cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335312

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22337954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22337954

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDS040

1 reference

11 August 2017

1 reference

11 August 2017

1 reference